Version 5.4
Homo sapiens Gene: CHCHD4
Summary
InnateDB Gene IDBG-19928.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHCHD4
Gene Name coiled-coil-helix-coiled-coil-helix domain containing 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163528
Encoded Proteins
IDBP-19930
coiled-coil-helix-coiled-coil-helix domain containing 4
IDBP-236511
coiled-coil-helix-coiled-coil-helix domain containing 4
IDBP-365154
coiled-coil-helix-coiled-coil-helix domain containing 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CHCHD4, a component of human mitochondria, belongs to a protein family whose members share 6 highly conserved cysteine residues constituting a -CXC-CX(9)C-CX(9)C- motif in the C terminus (Hofmann et al., 2005 [PubMed 16185709]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:14112077-14124870
Strand Reverse strand
Band p25.1
Transcripts
ENST00000295767 ENSP00000295767
ENST00000396914 ENSP00000380122
ENST00000420103 ENSP00000402716
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015035 protein disulfide oxidoreductase activity
Biological Process
GO:0006626 protein targeting to mitochondrion
GO:0022417 protein maturation by protein folding
GO:0044267 cellular protein metabolic process
GO:0045041 protein import into mitochondrial intermembrane space
GO:0051084 'de novo' posttranslational protein folding
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005758 mitochondrial intermembrane space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034203
View Gene Order
ENSBTAG00000015529
Not yet available
Pathways
NETPATH
REACTOME
REACT_118595
Mitochondrial protein import pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F8WDW7
UniProt Splice Variant
Entrez Gene 131474
UniGene Hs.517815 Hs.629024
RefSeq NM_001098502 NM_144636
HUGO HGNC:26467
OMIM 611077
CCDS CCDS2617 CCDS43054
HPRD 13045
IMGT
EMBL AC090004
GenPept
RNA Seq Atlas 131474

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca