Version 5.4
Mus musculus Gene: 1500003O03Rik
Summary
InnateDB Gene IDBG-199584.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol 1500003O03Rik
Gene Name RIKEN cDNA 1500003O03 gene
Synonyms 1500003O03Rik; AA960066; AI046351; Cahp; Chp; p24; Sid470p; vac
Species Mus musculus
Ensembl Gene ENSMUSG00000014077
Encoded Proteins
IDBP-199586
RIKEN cDNA 1500003O03 gene
IDBP-400083
RIKEN cDNA 1500003O03 gene
IDBP-542393
RIKEN cDNA 1500003O03 gene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187446:
This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:119547697-119587027
Strand Forward strand
Band E5
Transcripts
ENSMUST00000014221 ENSMUSP00000014221
ENSMUST00000119172 ENSMUSP00000114013
ENSMUST00000154406
ENSMUST00000132448 ENSMUSP00000122946
ENSMUST00000137585
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004860 protein kinase inhibitor activity
GO:0005215 transporter activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0019900 kinase binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0001578 microtubule bundle formation
GO:0001933 negative regulation of protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0006611 protein export from nucleus
GO:0010923 negative regulation of phosphatase activity
GO:0017156 calcium ion-dependent exocytosis
GO:0022406 membrane docking
GO:0031122 cytoplasmic microtubule organization
GO:0031397 negative regulation of protein ubiquitination
GO:0031953 negative regulation of protein autophosphorylation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032417 positive regulation of sodium:proton antiporter activity
GO:0042308 negative regulation of protein import into nucleus
GO:0045056 transcytosis
GO:0050821 protein stabilization
GO:0051222 positive regulation of protein transport
GO:0051259 protein oligomerization
GO:0051453 regulation of intracellular pH
GO:0060050 positive regulation of protein glycosylation
GO:0061024 membrane organization
GO:0061025 membrane fusion
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:0071468 cellular response to acidity
GO:0090314 positive regulation of protein targeting to membrane
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0015630 microtubule cytoskeleton
GO:0030133 transport vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000187446
View Gene Order
ENSBTAG00000027173
Not yet available
Pathways
NETPATH
REACTOME
REACT_222247
Glycosaminoglycan metabolism pathway
REACT_189085
Disease pathway
REACT_211754
MPS IV - Morquio syndrome B pathway
REACT_225132
MPS IV - Morquio syndrome A pathway
REACT_218935
MPS IIIC - Sanfilippo syndrome C pathway
REACT_188937
Metabolism pathway
REACT_224474
MPS I - Hurler syndrome pathway
REACT_227993
MPS IIID - Sanfilippo syndrome D pathway
REACT_269282
Defective B4GALT7 causes EDS, progeroid type pathway
REACT_270278
Diseases of glycosylation pathway
REACT_268957
Defective CHSY1 causes TPBS pathway
REACT_268952
Defective B3GAT3 causes JDSSDHD pathway
REACT_215504
MPS II - Hunter syndrome pathway
REACT_269263
Diseases associated with glycosaminoglycan metabolism pathway
REACT_196551
Hyaluronan metabolism pathway
REACT_196554
Hyaluronan uptake and degradation pathway
REACT_219946
MPS IX - Natowicz syndrome pathway
REACT_203949
Glycogen storage diseases pathway
REACT_208416
MPS VII - Sly syndrome pathway
REACT_271176
Defective CHST14 causes EDS, musculocontractural type pathway
REACT_269050
Defective CHST3 causes SEDCJD pathway
REACT_215179
MPS VI - Maroteaux-Lamy syndrome pathway
REACT_268667
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
REACT_221180
MPS IIIB - Sanfilippo syndrome B pathway
REACT_221189
MPS IIIA - Sanfilippo syndrome A pathway
REACT_270086
Defective PAPSS2 causes SEMD-PA pathway
REACT_271374
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
REACT_217438
Mucopolysaccharidoses pathway
REACT_269577
Defective CHST6 causes MCDC1 pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_248571
Metabolism of carbohydrates pathway
REACT_270174
Defective EXT2 causes exostoses 2 pathway
REACT_269276
Defective SLC26A2 causes chondrodysplasias pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_120996
Hyaluronan uptake and degradation pathway
REACT_147853
Mucopolysaccharidoses pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_267711
Defective B4GALT7 causes EDS, progeroid type pathway
REACT_267713
Defective CHST6 causes MCDC1 pathway
REACT_147719
MPS VI - Maroteaux-Lamy syndrome pathway
REACT_267645
Defective PAPSS2 causes SEMD-PA pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_147749
MPS IIID - Sanfilippo syndrome D pathway
REACT_267662
Defective SLC26A2 causes chondrodysplasias pathway
REACT_147739
MPS IX - Natowicz syndrome pathway
REACT_267674
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
REACT_267642
Defective CHST14 causes EDS, musculocontractural type pathway
REACT_147798
MPS IV - Morquio syndrome B pathway
REACT_267659
Defective B3GAT3 causes JDSSDHD pathway
REACT_267708
Defective CHST3 causes SEDCJD pathway
REACT_147825
MPS IV - Morquio syndrome A pathway
REACT_267654
Defective EXT2 causes exostoses 2 pathway
REACT_267707
Diseases associated with glycosaminoglycan metabolism pathway
REACT_147734
MPS II - Hunter syndrome pathway
REACT_267635
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
REACT_121315
Glycosaminoglycan metabolism pathway
REACT_267705
Diseases of glycosylation pathway
REACT_147759
MPS VII - Sly syndrome pathway
REACT_267682
Defective CHSY1 causes TPBS pathway
REACT_111217
Metabolism pathway
REACT_147857
MPS I - Hurler syndrome pathway
REACT_147753
MPS IIIA - Sanfilippo syndrome A pathway
REACT_121083
Hyaluronan metabolism pathway
REACT_147860
MPS IIIC - Sanfilippo syndrome C pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
REACT_147788
MPS IIIB - Sanfilippo syndrome B pathway
REACT_269304
Defective EXT2 causes exostoses 2 pathway
REACT_269658
Defective CHST6 causes MCDC1 pathway
REACT_216637
MPS IIIA - Sanfilippo syndrome A pathway
REACT_271434
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
REACT_268431
Defective PAPSS2 causes SEMD-PA pathway
REACT_221274
Metabolism of carbohydrates pathway
REACT_205556
Glycosaminoglycan metabolism pathway
REACT_270533
Defective CHSY1 causes TPBS pathway
REACT_204212
MPS I - Hurler syndrome pathway
REACT_224609
MPS IIID - Sanfilippo syndrome D pathway
REACT_268552
Diseases associated with glycosaminoglycan metabolism pathway
REACT_224746
Hyaluronan uptake and degradation pathway
REACT_226837
MPS IX - Natowicz syndrome pathway
REACT_219973
Myoclonic epilepsy of Lafora pathway
REACT_208504
MPS II - Hunter syndrome pathway
REACT_220414
MPS VII - Sly syndrome pathway
REACT_268766
Defective B3GAT3 causes JDSSDHD pathway
REACT_208051
Mucopolysaccharidoses pathway
REACT_268446
Diseases of glycosylation pathway
REACT_271537
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
REACT_220816
MPS IIIC - Sanfilippo syndrome C pathway
REACT_211129
Glycogen storage diseases pathway
REACT_212403
MPS IIIB - Sanfilippo syndrome B pathway
REACT_270161
Defective CHST3 causes SEDCJD pathway
REACT_219139
Metabolism pathway
REACT_269058
Defective B4GALT7 causes EDS, progeroid type pathway
REACT_269825
Defective SLC26A2 causes chondrodysplasias pathway
REACT_270962
Defective CHST14 causes EDS, musculocontractural type pathway
REACT_214749
Hyaluronan metabolism pathway
REACT_218915
MPS IV - Morquio syndrome A pathway
REACT_217121
MPS IV - Morquio syndrome B pathway
REACT_215576
MPS VI - Maroteaux-Lamy syndrome pathway
REACT_207087
Disease pathway
KEGG
INOH
PID NCI
tcrcalciumpathway
Calcium signaling in the CD4+ TCR pathway
nfat_3pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Cross-References
SwissProt P61022
TrEMBL B0R092
UniProt Splice Variant
Entrez Gene 56398
UniGene Mm.310368
RefSeq NM_019769 XM_003085105 XM_006543333
OMIM
CCDS CCDS16604
HPRD
IMGT
MGI ID MGI:1927185
MGI Symbol Chp1
EMBL AB025217 AK005067 AK045920 AK156588 AK166219 AK167179 AK167720 AK168284 AK169146 AL844536 BC054733 BC064784
GenPept AAH54733 AAH64784 BAA84688 BAB23791 BAC32532 BAE33769 BAE38637 BAE39314 BAE39762 BAE40230 BAE40925
RNA Seq Atlas 100504089 102643165 56398

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca