InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gpx1

Summary

InnateDB Gene

IDBG-199664.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpx1

Gene Name

glutathione peroxidase 1

Synonyms

AI195024; AL033363; CGPx; Gpx; GPx-1; GSHPx-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000063856

Encoded Proteins

IDBP-199666

glutathione peroxidase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene product belongs to the family of glutathione peroxidase, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3\' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:108339080-108340338

Strand

Forward strand

Band

Transcripts

ENSMUST00000082429

ENSMUSP00000081010

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004602	glutathione peroxidase activity
GO:0004866	endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008430	selenium binding
GO:0017124	SH3 domain binding
GO:0043295	glutathione binding
GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity

Biological Process

GO:0000302	response to reactive oxygen species
GO:0001659	temperature homeostasis
GO:0001885	endothelial cell development
GO:0002862	negative regulation of inflammatory response to antigenic stimulus
GO:0006629	lipid metabolic process
GO:0006641	triglyceride metabolic process
GO:0006749	glutathione metabolic process
GO:0006915	apoptotic process
GO:0006979	response to oxidative stress
GO:0006982	response to lipid hydroperoxide
GO:0007568	aging
GO:0007605	sensory perception of sound
GO:0008283	cell proliferation
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009410	response to xenobiotic stimulus
GO:0009609	response to symbiotic bacterium
GO:0009611	response to wounding
GO:0009636	response to toxic substance
GO:0009650	UV protection
GO:0009725	response to hormone
GO:0009749	response to glucose
GO:0010269	response to selenium ion
GO:0010332	response to gamma radiation
GO:0014070	response to organic cyclic compound
GO:0014902	myotube differentiation
GO:0018158	protein oxidation
GO:0032355	response to estradiol
GO:0033194	response to hydroperoxide
GO:0033599	regulation of mammary gland epithelial cell proliferation
GO:0035094	response to nicotine
GO:0040029	regulation of gene expression, epigenetic
GO:0042311	vasodilation
GO:0042542	response to hydrogen peroxide
GO:0042744	hydrogen peroxide catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043403	skeletal muscle tissue regeneration
GO:0043523	regulation of neuron apoptotic process
GO:0043534	blood vessel endothelial cell migration
GO:0045444	fat cell differentiation
GO:0045454	cell redox homeostasis
GO:0048741	skeletal muscle fiber development
GO:0051450	myoblast proliferation
GO:0051593	response to folic acid
GO:0051702	interaction with symbiont
GO:0051897	positive regulation of protein kinase B signaling
GO:0055114	oxidation-reduction process
GO:0060047	heart contraction
GO:0060055	angiogenesis involved in wound healing
GO:0061136	regulation of proteasomal protein catabolic process
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway