Version 5.4
Homo sapiens Gene: TNNI2
Summary
InnateDB Gene IDBG-19973.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNNI2
Gene Name troponin I type 2 (skeletal, fast)
Synonyms AMCD2B; DA2B; FSSV; fsTnI
Species Homo sapiens
Ensembl Gene ENSG00000130598
Encoded Proteins
IDBP-19975
troponin I type 2 (skeletal, fast)
IDBP-19977
troponin I type 2 (skeletal, fast)
IDBP-19979
troponin I type 2 (skeletal, fast)
IDBP-19981
troponin I type 2 (skeletal, fast)
IDBP-809060
troponin I type 2 (skeletal, fast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:1838989-1841680
Strand Forward strand
Band p15.5
Transcripts
ENST00000381911 ENSP00000371336
ENST00000381906 ENSP00000371331
ENST00000252898 ENSP00000252898
ENST00000381905 ENSP00000371330
ENST00000468473
ENST00000617947 ENSP00000481242
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0031014 troponin T binding
Biological Process
GO:0003009 skeletal muscle contraction
GO:0006937 regulation of muscle contraction
GO:0030049 muscle filament sliding
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005861 troponin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031097
View Gene Order
ENSBTAG00000010880
Not yet available
Pathways
NETPATH
REACTOME
REACT_16969
Striated Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.523403 Hs.713044
RefSeq NM_001145829 NM_001145841 NM_003282
HUGO
OMIM
CCDS CCDS31333 CCDS53594
HPRD 01843
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca