InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rab4a

Summary

InnateDB Gene

IDBG-199736.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab4a

Gene Name

RAB4A, member RAS oncogene family

Synonyms

AI848268; Rab4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019478

Encoded Proteins

IDBP-400345

RAB4A, member RAS oncogene family

IDBP-400344

RAB4A, member RAS oncogene family

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168118:
This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:123805985-123835287

Strand

Forward strand

Band

Transcripts

ENSMUST00000118535	ENSMUSP00000113886
ENSMUST00000117702	ENSMUSP00000113401

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008565	protein transporter activity
GO:0019003	GDP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0019882	antigen processing and presentation
GO:0030100	regulation of endocytosis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0016020	membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0031982	vesicle
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000168118

View Gene Order

ENSBTAG00000018857

Not yet available

Pathways

NETPATH

REACTOME

REACT_209837

Membrane Trafficking pathway

REACT_199054

Translocation of GLUT4 to the plasma membrane pathway

KEGG

mmu04144

Endocytosis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_147867

Translocation of GLUT4 to the plasma membrane pathway

REACT_11123

Membrane Trafficking pathway

REACT_217718

Translocation of GLUT4 to the plasma membrane pathway

REACT_213260

Membrane Trafficking pathway

KEGG

hsa04144

Endocytosis pathway

INOH

PID NCI

tcptp_pathway

Signaling events mediated by TCPTP

pdgfrbpathway

PDGFR-beta signaling pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.9221

RefSeq

NM_009003

OMIM

CCDS

CCDS52703

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas