Version 5.4
Homo sapiens Gene: DEGS2
Summary
InnateDB Gene IDBG-20008.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DEGS2
Gene Name delta(4)-desaturase, sphingolipid 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168350
Encoded Proteins
IDBP-20010
degenerative spermatocyte homolog 2, lipid desaturase (Drosophila)
IDBP-599726
degenerative spermatocyte homolog 2, lipid desaturase (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:100143957-100160163
Strand Reverse strand
Band q32.2
Transcripts
ENST00000305631 ENSP00000307126
ENST00000553834 ENSP00000450637
ENST00000557117
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000170 sphingosine hydroxylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0042284 sphingolipid delta-4 desaturase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006665 sphingolipid metabolic process
GO:0006667 sphinganine metabolic process
GO:0030148 sphingolipid biosynthetic process
GO:0044281 small molecule metabolic process
GO:0046513 ceramide biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021263
View Gene Order
ENSBTAG00000009294
Not yet available
Pathways
NETPATH
REACTOME
REACT_115810
Sphingolipid de novo biosynthesis pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00600
Sphingolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.159643
RefSeq NM_206918 XM_006720043
HUGO
OMIM
CCDS CCDS9956
HPRD 13134
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca