InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Htr6

Summary

InnateDB Gene

IDBG-200185.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Htr6

Gene Name

5-hydroxytryptamine (serotonin) receptor 6

Synonyms

5-HT6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028747

Encoded Proteins

IDBP-200187

5-hydroxytryptamine (serotonin) receptor 6

IDBP-270094

5-hydroxytryptamine (serotonin) receptor 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158748:
This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:139061108-139075570

Strand

Reverse strand

Band

Transcripts

ENSMUST00000068036	ENSMUSP00000068333
ENSMUST00000105802	ENSMUSP00000101428

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007210	serotonin receptor signaling pathway
GO:0007420	brain development
GO:0007612	learning
GO:0014050	negative regulation of glutamate secretion
GO:0014053	negative regulation of gamma-aminobutyric acid secretion
GO:0014054	positive regulation of gamma-aminobutyric acid secretion
GO:0014058	negative regulation of acetylcholine secretion, neurotransmission
GO:0032355	response to estradiol
GO:0033603	positive regulation of dopamine secretion
GO:0042493	response to drug
GO:0060291	long-term synaptic potentiation