Version 5.4
Mus musculus Gene: Akr7a5
Summary
InnateDB Gene IDBG-200384.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Akr7a5
Gene Name aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase)
Synonyms 0610025K21Rik; Afar; Afar1; Akr7a2
Species Mus musculus
Ensembl Gene ENSMUSG00000028743
Encoded Proteins
IDBP-200386
aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000053371:
The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:139310744-139318426
Strand Forward strand
Band D3
Transcripts
ENSMUST00000073787 ENSMUSP00000073459
ENSMUST00000153645
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004032 alditol:NADP+ 1-oxidoreductase activity
Biological Process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000053371
View Gene Order
Pathways
NETPATH
REACTOME
REACT_237136
Aflatoxin activation and detoxification pathway
REACT_188937
Metabolism pathway
REACT_232343
Biological oxidations pathway
KEGG
mmu00980
Metabolism of xenobiotics by cytochrome P450 pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228214
Aflatoxin activation and detoxification pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
INOH
PID NCI
Cross-References
SwissProt Q8CG76
TrEMBL
UniProt Splice Variant
Entrez Gene 110198
UniGene Mm.482154
RefSeq NM_025337
OMIM
CCDS CCDS18844
HPRD
IMGT
MGI ID MGI:107796
MGI Symbol Akr7a5
EMBL AF525358 AJ271800 AJ271801 AK143203 AL807811 BC031857 BK000393
GenPept AAH31857 AAO38437 BAE25302 CAC81077 CAC81078 CAM18543 DAA00087
RNA Seq Atlas 110198

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca