InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Egln1

Summary

InnateDB Gene

IDBG-200540.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Egln1

Gene Name

EGL nine homolog 1 (C. elegans)

Synonyms

AI503754; C1orf12; Hif-p4h-2; HIF-PH2; HPH-2; ORF13; Phd2; SM-20

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031987

Encoded Proteins

IDBP-200542

EGL nine homolog 1 (C. elegans)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135766:
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:124908596-124949254

Strand

Reverse strand

Band

Transcripts

ENSMUST00000034469

ENSMUSP00000034469

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0019899	enzyme binding
GO:0031418	L-ascorbic acid binding
GO:0031543	peptidyl-proline dioxygenase activity
GO:0031545	peptidyl-proline 4-dioxygenase activity

Biological Process

GO:0001666	response to hypoxia
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0030821	negative regulation of cAMP catabolic process
GO:0032364	oxygen homeostasis
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045765	regulation of angiogenesis
GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:0055008	cardiac muscle tissue morphogenesis
GO:0055114	oxidation-reduction process
GO:0060347	heart trabecula formation
GO:0060412	ventricular septum morphogenesis
GO:0060711	labyrinthine layer development
GO:0071731	response to nitric oxide