Version 5.4
Mus musculus Gene: Uvrag
Summary
InnateDB Gene IDBG-200543.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Uvrag
Gene Name UV radiation resistance associated gene
Synonyms 9530039D02Rik; AI648770; BB124205; Uvrag1; Uvragl
Species Mus musculus
Ensembl Gene ENSMUSG00000035354
Encoded Proteins
IDBP-200545
UV radiation resistance associated gene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25917095
Mir125a regulates the innate host defense by inhibiting the activation of autophagy and antimicrobial effects against Mycobacterium tuberculosis through targeting Uvrag.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198382:
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:98886743-99141144
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000037968 ENSMUSP00000045297
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000149 SNARE binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0010508 positive regulation of autophagy
GO:0035493 SNARE complex assembly
GO:0045087 innate immune response (InnateDB)
GO:0046718 viral entry into host cell
Cellular Component
GO:0005764 lysosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0043234 protein complex
GO:0045335 phagocytic vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198382
View Gene Order
ENSBTAG00000016355
Not yet available
Cross-References
SwissProt
TrEMBL Q8C0K8
UniProt Splice Variant
Entrez Gene 78610
UniGene Mm.323072 Mm.413095
RefSeq NM_178635
OMIM
CCDS CCDS21476
HPRD
IMGT
MGI ID MGI:1925860
MGI Symbol Uvrag
EMBL AC093351 AC115850 AK030814 AK154903
GenPept BAC27144 BAE32914
RNA Seq Atlas 78610

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca