Version 5.4
Mus musculus Gene: Serpinh1
Summary
InnateDB Gene IDBG-200623.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Serpinh1
Gene Name serine (or cysteine) peptidase inhibitor, clade H, member 1
Synonyms BERF-1; Cbp1; Cbp2; gp46; Hsp47; J6; Serpinh2
Species Mus musculus
Ensembl Gene ENSMUSG00000070436
Encoded Proteins
IDBP-200627
serine (or cysteine) peptidase inhibitor, clade H, member 1
IDBP-624265
serine (or cysteine) peptidase inhibitor, clade H, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149257:
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:99345375-99353230
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000094154 ENSMUSP00000091706
ENSMUST00000169437 ENSMUSP00000126390
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 61 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0051082 unfolded protein binding
Biological Process
GO:0003433 chondrocyte development involved in endochondral bone morphogenesis
GO:0006950 response to stress
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
GO:0030199 collagen fibril organization
GO:0032964 collagen biosynthetic process
GO:0051604 protein maturation
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000149257
View Gene Order
ENSBTAG00000001027
Not yet available
Pathways
NETPATH
REACTOME
REACT_199045
Collagen formation pathway
REACT_198984
Collagen biosynthesis and modifying enzymes pathway
REACT_206066
Extracellular matrix organization pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121139
Collagen biosynthesis and modifying enzymes pathway
REACT_118779
Extracellular matrix organization pathway
REACT_120729
Collagen formation pathway
REACT_206550
Collagen formation pathway
REACT_215758
Collagen biosynthesis and modifying enzymes pathway
REACT_223425
Extracellular matrix organization pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P19324
TrEMBL
UniProt Splice Variant
Entrez Gene 12406
UniGene Mm.22708
RefSeq NM_001111043 NM_001111044 NM_001285776 NM_009825 XM_006507279
OMIM
CCDS CCDS21480
HPRD
IMGT
MGI ID MGI:88283
MGI Symbol Serpinh1
EMBL AC158748 AK029080 AK031457 AK077660 AK077937 AK086519 AK086523 AK089993 AK090103 AK159998 AK168442 AK168870 BC085143 D12907 J05609 X60676
GenPept AAA03200 AAH85143 BAA02298 BAC26283 BAC27413 BAC36935 BAC37075 BAC39683 BAC39684 BAC41032 BAC41093 BAE35546 BAE40347 BAE40689 CAA43091
RNA Seq Atlas 12406

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca