Version 5.4
Homo sapiens Gene: SLC6A6
Summary
InnateDB Gene IDBG-20066.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC6A6
Gene Name solute carrier family 6 (neurotransmitter transporter, taurine), member 6
Synonyms TAUT
Species Homo sapiens
Ensembl Gene ENSG00000131389
Encoded Proteins
IDBP-365402
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
IDBP-365405
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
IDBP-813486
solute carrier family 6 (neurotransmitter transporter), member 6
IDBP-813495
solute carrier family 6 (neurotransmitter transporter), member 6
IDBP-813496
solute carrier family 6 (neurotransmitter transporter), member 6
IDBP-813498
solute carrier family 6 (neurotransmitter transporter), member 6
IDBP-813499
solute carrier family 6 (neurotransmitter transporter), member 6
IDBP-813501
solute carrier family 6 (neurotransmitter transporter), member 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Taurine (2-aminoethanesulfonic acid) is a major intracellular amino acid in mammals. It is involved in a number of important physiologic processes, including bile acid conjugation in hepatocytes, modulation of calcium flux and neural excitability, osmoregulation, detoxification, and membrane stabilization. The cells of most organisms respond to hypertonicity by the intracellular accumulation of high concentrations of small organic solutes (osmolytes) that, in contrast to high concentrations of electrolytes, do not perturb the function of macromolecules. The renal medulla is normally the only tissue in mammals that undergoes wide shifts in tonicity. Its hypertonicity when the kidney is excreting a concentrated urine is fundamental to water conservation. The taurine content of the renal medulla of rats infused with 5% NaCl is higher than that in controls, suggesting that taurine behaves as an osmolyte in the renal medulla. Indeed, taurine functions as an osmolyte in Madin-Darby canine kidney (MDCK) cells. When MDCK cells cultured in isotonic medium are switched to hypertonic medium, their content of taurine doubles through the taking up of taurine from the medium. Taurine transport in these cells is dependent on sodium and chloride ions and is localized primarily in the basolateral plasma membrane (summary by Uchida et al., 1992 [PubMed 1518851]).[supplied by OMIM, Jan 2011]
This gene encodes a multi-pass membrane protein that is a member of a family of sodium and chloride-ion dependent transporters. The encoded protein transports taurine and beta-alanine. There is a pseudogene for this gene on chromosome 21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:14402576-14489349
Strand Forward strand
Band p25.1
Transcripts
ENST00000452775 ENSP00000402059
ENST00000452151 ENSP00000399522
ENST00000622810
ENST00000610642 ENSP00000482391
ENST00000613060 ENSP00000481625
ENST00000618278 ENSP00000481946
ENST00000621751 ENSP00000482560
ENST00000613930
ENST00000622176 ENSP00000482220
ENST00000615188
ENST00000622186 ENSP00000480890
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005328 neurotransmitter:sodium symporter activity
GO:0005368 taurine transmembrane transporter activity
GO:0005369 taurine:sodium symporter activity
GO:0030977 taurine binding
Biological Process
GO:0006520 cellular amino acid metabolic process
GO:0006810 transport
GO:0006811 ion transport
GO:0006836 neurotransmitter transport
GO:0006865 amino acid transport
GO:0015734 taurine transport
GO:0015849 organic acid transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030096
View Gene Order
ENSBTAG00000011088
Not yet available
Pathways
NETPATH
REACTOME
REACT_20506
Na+/Cl- dependent neurotransmitter transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_13796
Amino acid transport across the plasma membrane pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 6533
UniGene
RefSeq NM_001134367 NM_001134368 NM_003043 XM_006713307
HUGO HGNC:11052
OMIM 186854
CCDS CCDS33705 CCDS46765
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 6533

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca