InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ucp2

Summary

InnateDB Gene

IDBG-201460.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ucp2

Gene Name

uncoupling protein 2 (mitochondrial, proton carrier)

Synonyms

Slc25a8

Species

Mus musculus

Ensembl Gene

ENSMUSG00000033685

Encoded Proteins

IDBP-533811

uncoupling protein 2 (mitochondrial, proton carrier)

IDBP-531629

uncoupling protein 2 (mitochondrial, proton carrier)

IDBP-537325

uncoupling protein 2 (mitochondrial, proton carrier)

IDBP-538553

uncoupling protein 2 (mitochondrial, proton carrier)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23988448

[Homo sapiens] MIR133A1 enhances CASP1 activation and IL1B processing and suppresses inflammasome activation by suppressing its target UCP2

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175567:
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5\'-UCP3-UCP2-3\'. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:100493337-100502020

Strand

Forward strand

Band

Transcripts

ENSMUST00000126534	ENSMUSP00000120967
ENSMUST00000126381
ENSMUST00000129324	ENSMUSP00000115648
ENSMUST00000153287	ENSMUSP00000115953
ENSMUST00000133044	ENSMUSP00000115598
ENSMUST00000151221
ENSMUST00000133498
ENSMUST00000138673
ENSMUST00000149808

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0000303	response to superoxide
GO:0001666	response to hypoxia
GO:0006839	mitochondrial transport
GO:0007565	female pregnancy
GO:0007568	aging
GO:0009749	response to glucose
GO:0010942	positive regulation of cell death
GO:0032869	cellular response to insulin stimulus
GO:0032870	cellular response to hormone stimulus
GO:0034198	cellular response to amino acid starvation
GO:0043066	negative regulation of apoptotic process
GO:0051881	regulation of mitochondrial membrane potential
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070542	response to fatty acid
GO:0071333	cellular response to glucose stimulus
GO:0097421	liver regeneration