Version 5.4
Mus musculus Gene: Nme6
Summary
InnateDB Gene IDBG-201567.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nme6
Gene Name NME/NM23 nucleoside diphosphate kinase 6
Synonyms nm23-M6
Species Mus musculus
Ensembl Gene ENSMUSG00000032478
Encoded Proteins
IDBP-201569
non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)
IDBP-400310
non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)
IDBP-400309
non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)
IDBP-536337
non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)
IDBP-538258
non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172113:
Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:109832749-109843116
Strand Forward strand
Band F2
Transcripts
ENSMUST00000035053 ENSMUSP00000035053
ENSMUST00000122343 ENSMUSP00000113692
ENSMUST00000119376 ENSMUSP00000112384
ENSMUST00000147777 ENSMUSP00000119531
ENSMUST00000141097
ENSMUST00000145376
ENSMUST00000133483 ENSMUSP00000116547
ENSMUST00000128984
ENSMUST00000142544
ENSMUST00000143211
ENSMUST00000138461
ENSMUST00000148967
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004550 nucleoside diphosphate kinase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006183 GTP biosynthetic process
GO:0006228 UTP biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0030308 negative regulation of cell growth
GO:0045839 negative regulation of mitosis
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000172113
View Gene Order
ENSBTAG00000003025
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00240
Pyrimidine metabolism pathway
mmu00230
Purine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00230
Purine metabolism pathway
INOH
INOH website
Folate metabolism pathway
INOH website
Purine nucleotides nucleosides metabolism pathway
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_018757 XM_006512197
OMIM
CCDS CCDS23558
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca