Version 5.4
Mus musculus Gene: Prrx1
Summary
InnateDB Gene IDBG-202100.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prrx1
Gene Name paired related homeobox 1
Synonyms A230024N07Rik; AA755424; AI385634; AI843499; K-2; mHox; Pmx; Pmx1; Prx1
Species Mus musculus
Ensembl Gene ENSMUSG00000026586
Encoded Proteins
IDBP-202102
paired related homeobox 1
IDBP-202104
paired related homeobox 1
IDBP-622458
paired related homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116132:
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:163245119-163313710
Strand Reverse strand
Band H2.1
Transcripts
ENSMUST00000027878 ENSMUSP00000027878
ENSMUST00000075805 ENSMUSP00000075203
ENSMUST00000174397 ENSMUSP00000134338
ENSMUST00000174098
ENSMUST00000183691
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0071837 HMG box domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0006355 regulation of transcription, DNA-templated
GO:0030326 embryonic limb morphogenesis
GO:0042472 inner ear morphogenesis
GO:0042474 middle ear morphogenesis
GO:0045880 positive regulation of smoothened signaling pathway
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048844 artery morphogenesis
GO:0051216 cartilage development
GO:0060021 palate development
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116132
View Gene Order
ENSBTAG00000004570
Not yet available
Cross-References
SwissProt
TrEMBL G3UZ44 Q3TMI4
UniProt Splice Variant
Entrez Gene 18933
UniGene Mm.288642 Mm.407196 Mm.412962 Mm.454402
RefSeq NM_001025570 NM_011127 NM_175686 XM_006496703
OMIM
CCDS CCDS56651 CCDS15427 CCDS15428
HPRD
IMGT
MGI ID MGI:97712
MGI Symbol Prrx1
EMBL AC120173 AK165914
GenPept BAE38458
RNA Seq Atlas 18933

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca