InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Numa1

Summary

InnateDB Gene

IDBG-202359.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Numa1

Gene Name

nuclear mitotic apparatus protein 1

Synonyms

6720401E04Rik; AA764025; AL022610; AU014979

Species

Mus musculus

Ensembl Gene

ENSMUSG00000066306

Encoded Proteins

IDBP-202363

nuclear mitotic apparatus protein 1

IDBP-626419

nuclear mitotic apparatus protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137497:
This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:101969843-102014959

Strand

Forward strand

Band

Transcripts

ENSMUST00000084852	ENSMUSP00000081912
ENSMUST00000163183	ENSMUSP00000126180

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0008017	microtubule binding

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0051321	meiotic cell cycle
GO:0060487	lung epithelial cell differentiation

Cellular Component

GO:0000139	Golgi membrane
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005876	spindle microtubule
GO:0016363	nuclear matrix
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0045177	apical part of cell