Version 5.4
Mus musculus Gene: Myl3
Summary
InnateDB Gene IDBG-202370.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Myl3
Gene Name myosin, light polypeptide 3
Synonyms MLC1s; MLC1v; Mylc; VLC1
Species Mus musculus
Ensembl Gene ENSMUSG00000059741
Encoded Proteins
IDBP-202372
myosin, light polypeptide 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160808:
MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:110763646-110769804
Strand Forward strand
Band F2
Transcripts
ENSMUST00000079784 ENSMUSP00000078715
ENSMUST00000124267
ENSMUST00000136695
ENSMUST00000153142
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0003785 actin monomer binding
GO:0005509 calcium ion binding
Biological Process
GO:0002026 regulation of the force of heart contraction
GO:0006942 regulation of striated muscle contraction
GO:0007519 skeletal muscle tissue development
GO:0008152 metabolic process
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0016459 myosin complex
GO:0031672 A band
GO:0031674 I band
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000160808
View Gene Order
ENSBTAG00000008394
Not yet available
Pathways
NETPATH
REACTOME
REACT_232053
Striated Muscle Contraction pathway
REACT_262759
Muscle contraction pathway
KEGG
mmu04260
Cardiac muscle contraction pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_16969
Striated Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
REACT_213099
Muscle contraction pathway
REACT_223821
Striated Muscle Contraction pathway
KEGG
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa04260
Cardiac muscle contraction pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_010859
OMIM
CCDS CCDS23571
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca