InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Xcl1

Summary

InnateDB Gene

IDBG-202545.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Xcl1

Gene Name

chemokine (C motif) ligand 1

Synonyms

AI661682; ATAC; Lptn; LTN; SCM-1; SCM-1a; Scyc1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026573

Encoded Proteins

IDBP-202547

chemokine (C motif) ligand 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143184:
This gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Nov 2010]
This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:164931644-164935527

Strand

Reverse strand

Band

H2.2

Transcripts

ENSMUST00000027860

ENSMUSP00000027860

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity
GO:0042379	chemokine receptor binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002690	positive regulation of leukocyte chemotaxis
GO:0002726	positive regulation of T cell cytokine production
GO:0002839	positive regulation of immune response to tumor cell
GO:0006935	chemotaxis
GO:0006955	immune response
GO:0010820	positive regulation of T cell chemotaxis
GO:0032689	negative regulation of interferon-gamma production
GO:0032703	negative regulation of interleukin-2 production
GO:0032733	positive regulation of interleukin-10 production
GO:0035782	mature natural killer cell chemotaxis
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045089	positive regulation of innate immune response
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050727	regulation of inflammatory response
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0071353	cellular response to interleukin-4
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0071636	positive regulation of transforming growth factor beta production
GO:0071663	positive regulation of granzyme B production
GO:0090023	positive regulation of neutrophil chemotaxis
GO:2000412	positive regulation of thymocyte migration
GO:2000503	positive regulation of natural killer cell chemotaxis
GO:2000513	positive regulation of granzyme A production
GO:2000518	negative regulation of T-helper 1 cell activation
GO:2000538	positive regulation of B cell chemotaxis
GO:2000553	positive regulation of T-helper 2 cell cytokine production
GO:2000556	positive regulation of T-helper 1 cell cytokine production
GO:2000558	positive regulation of immunoglobulin production in mucosal tissue
GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation
GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation
GO:2000566	positive regulation of CD8-positive, alpha-beta T cell proliferation