InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gatm

Summary

InnateDB Gene

IDBG-203087.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gatm

Gene Name

glycine amidinotransferase (L-arginine:glycine amidinotransferase)

Synonyms

1810003P21Rik; AI314789; AT

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027199

Encoded Proteins

IDBP-203089

glycine amidinotransferase (L-arginine:glycine amidinotransferase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171766:
This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by mental retardation, language impairment, and behavioral disorders. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:122594467-122611303

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028624	ENSMUSP00000028624
ENSMUST00000154598
ENSMUST00000140808

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015067	amidinotransferase activity
GO:0015068	glycine amidinotransferase activity
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

Biological Process

GO:0006601	creatine biosynthetic process
GO:0006979	response to oxidative stress
GO:0007584	response to nutrient
GO:0009790	embryo development
GO:0010033	response to organic substance
GO:0042246	tissue regeneration
GO:0043434	response to peptide hormone
GO:0046689	response to mercury ion