InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Uck2

Summary

InnateDB Gene

IDBG-203179.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Uck2

Gene Name

uridine-cytidine kinase 2

Synonyms

AA407809; AI481316; AU018180; AU020720; TSA903; UK; UMK; Umpk

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026558

Encoded Proteins

IDBP-203181

uridine-cytidine kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143179:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]
This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:167226090-167285127

Strand

Reverse strand

Band

H2.3

Transcripts

ENSMUST00000027839

ENSMUSP00000027839

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004140	dephospho-CoA kinase activity
GO:0004849	uridine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0019206	nucleoside kinase activity

Biological Process

GO:0007631	feeding behavior
GO:0008152	metabolic process
GO:0015937	coenzyme A biosynthetic process
GO:0016310	phosphorylation
GO:0044206	UMP salvage
GO:0044211	CTP salvage
GO:0048678	response to axon injury
GO:0071453	cellular response to oxygen levels