InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Stx1a

Summary

InnateDB Gene

IDBG-203389.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stx1a

Gene Name

syntaxin 1A (brain)

Synonyms

HPC-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000007207

Encoded Proteins

IDBP-203391

syntaxin 1A (brain)

IDBP-542754

syntaxin 1A (brain)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106089:
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:135023482-135051100

Strand

Forward strand

Band

Transcripts

ENSMUST00000005509	ENSMUSP00000005509
ENSMUST00000150838	ENSMUSP00000117144
ENSMUST00000133812
ENSMUST00000156626
ENSMUST00000144198

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0001948	glycoprotein binding
GO:0005484	SNAP receptor activity
GO:0005515	protein binding
GO:0017022	myosin binding
GO:0019855	calcium channel inhibitor activity
GO:0019904	protein domain specific binding
GO:0030674	protein binding, bridging
GO:0032028	myosin head/neck binding
GO:0043008	ATP-dependent protein binding
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001956	positive regulation of neurotransmitter secretion
GO:0006886	intracellular protein transport
GO:0009629	response to gravity
GO:0016081	synaptic vesicle docking involved in exocytosis
GO:0016192	vesicle-mediated transport
GO:0017156	calcium ion-dependent exocytosis
GO:0017157	regulation of exocytosis
GO:0045921	positive regulation of exocytosis

Cellular Component

GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030141	secretory granule
GO:0030672	synaptic vesicle membrane
GO:0031201	SNARE complex
GO:0042641	actomyosin
GO:0043005	neuron projection
GO:0043229	intracellular organelle
GO:0043234	protein complex
GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex