Version 5.4
Homo sapiens Gene: DSG4
Summary
InnateDB Gene IDBG-2037.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DSG4
Gene Name desmoglein 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000175065
Encoded Proteins
IDBP-2039
desmoglein 4
IDBP-2041
desmoglein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the desmoglein subgroup of desmosomal cadherins. The encoded protein is a transmembrane component in desmosomes and may play a role in cell-cell adhesion in epithelial cells. Mutations in the gene are associated with localized autosomal recessive hypotrichosis and potentially in other skin disorders. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:31376777-31414912
Strand Forward strand
Band q12.1
Transcripts
ENST00000308128 ENSP00000311859
ENST00000359747 ENSP00000352785
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0001942 hair follicle development
GO:0007156 homophilic cell adhesion
GO:0016337 single organismal cell-cell adhesion
GO:0030216 keratinocyte differentiation
GO:0030509 BMP signaling pathway
GO:0042640 anagen
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030057 desmosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001804
View Gene Order
ENSBTAG00000040126
Not yet available
Cross-References
SwissProt Q86SJ6
TrEMBL
UniProt Splice Variant
Entrez Gene 147409
UniGene Hs.407618
RefSeq NM_001134453 NM_177986
HUGO HGNC:21307
OMIM 607892
CCDS CCDS11897 CCDS45845
HPRD
IMGT
EMBL AY168788 AY177663 AY177664 AY227350 AY228236 BC039098 BC132907 BC132909
GenPept AAH39098 AAI32908 AAI32910 AAO43657 AAO47077 AAO47078 AAP45000 AAP49811
RNA Seq Atlas 147409

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca