InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Plod1

Summary

InnateDB Gene

IDBG-203873.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plod1

Gene Name

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1

Synonyms

2410042F05Rik; AI854890; AV007929; Lh1; Plod

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019055

Encoded Proteins

IDBP-203875

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1

IDBP-270298

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1

IDBP-540650

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000083444:
Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:147909753-147936767

Strand

Reverse strand

Band

Transcripts

ENSMUST00000019199	ENSMUSP00000019199
ENSMUST00000105712	ENSMUSP00000101337
ENSMUST00000149129	ENSMUSP00000118857
ENSMUST00000124292
ENSMUST00000124041
ENSMUST00000132075

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008475	procollagen-lysine 5-dioxygenase activity
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418	L-ascorbic acid binding

Biological Process

GO:0001666	response to hypoxia
GO:0055114	oxidation-reduction process

Cellular Component

GO:0030867	rough endoplasmic reticulum membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000083444

View Gene Order

ENSBTAG00000002052

Not yet available

Pathways

NETPATH

REACTOME

REACT_199045

Collagen formation pathway

REACT_198984

Collagen biosynthesis and modifying enzymes pathway

REACT_206066

Extracellular matrix organization pathway

KEGG

mmu00310

Lysine degradation pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_121139

Collagen biosynthesis and modifying enzymes pathway

REACT_118779

Extracellular matrix organization pathway

REACT_120729

Collagen formation pathway

KEGG

hsa00310

Lysine degradation pathway

INOH

PID NCI

Cross-References

SwissProt

Q9R0E2

TrEMBL

Q3TZN4 Q91Z26

UniProt Splice Variant

Entrez Gene

18822

UniGene

Mm.37371 Mm.414132

RefSeq

NM_011122

OMIM

CCDS

CCDS18924

HPRD

IMGT

MGI ID

MGI:99907

MGI Symbol

Plod1

EMBL

AF046782 AK157729 BC006599 BC010268

GenPept

AAD54617 AAH06599 AAH10268 BAE34174

RNA Seq Atlas

18822