InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ndufs2

Summary

InnateDB Gene

IDBG-204242.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndufs2

Gene Name

NADH dehydrogenase (ubiquinone) Fe-S protein 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000013593

Encoded Proteins

IDBP-204244

NADH dehydrogenase (ubiquinone) Fe-S protein 2

IDBP-258391

NADH dehydrogenase (ubiquinone) Fe-S protein 2

IDBP-538630

NADH dehydrogenase (ubiquinone) Fe-S protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158864:
The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:171234853-171247122

Strand

Reverse strand

Band

Transcripts

ENSMUST00000013737	ENSMUSP00000013737
ENSMUST00000111318	ENSMUSP00000106950
ENSMUST00000136976
ENSMUST00000150108
ENSMUST00000138069
ENSMUST00000131286	ENSMUSP00000121397

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003954	NADH dehydrogenase activity
GO:0005515	protein binding
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0016651	oxidoreductase activity, acting on NAD(P)H
GO:0046872	metal ion binding
GO:0048038	quinone binding
GO:0051287	NAD binding
GO:0051539	4 iron, 4 sulfur cluster binding