Version 5.4
Mus musculus Gene: Sppl2a
Summary
InnateDB Gene IDBG-204467.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sppl2a
Gene Name signal peptide peptidase like 2A
Synonyms 2010106G01Rik; C130089K23Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000027366
Encoded Proteins
IDBP-204469
RIKEN cDNA 2010106G01 gene
IDBP-540507
RIKEN cDNA 2010106G01 gene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138600:
This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:126890391-126933235
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000028844 ENSMUSP00000028844
ENSMUST00000143700 ENSMUSP00000119064
ENSMUST00000125592
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004190 aspartic-type endopeptidase activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006509 membrane protein ectodomain proteolysis
GO:0031293 membrane protein intracellular domain proteolysis
GO:0050776 regulation of immune response
Cellular Component
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030660 Golgi-associated vesicle membrane
GO:0031902 late endosome membrane
GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000138600
View Gene Order
ENSBTAG00000011831
Not yet available
Cross-References
SwissProt Q9JJF9
TrEMBL Q9CPY9
UniProt Splice Variant
Entrez Gene 66552
UniGene Mm.269928
RefSeq NM_023220
OMIM
CCDS CCDS16690
HPRD
IMGT
MGI ID MGI:1913802
MGI Symbol Sppl2a
EMBL AB041547 AK008294 AK008328 AL732330 AL928836 BC026578 CH466519
GenPept AAH26578 BAA95032 BAB25583 BAB25606 CAM14542 CAM18333 EDL28169
RNA Seq Atlas 66552

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca