Version 5.4
Homo sapiens Gene: RNF170
Summary
InnateDB Gene IDBG-20449.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF170
Gene Name ring finger protein 170
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000120925
Encoded Proteins
IDBP-20451
ring finger protein 170
IDBP-20453
ring finger protein 170
IDBP-20455
ring finger protein 170
IDBP-593244
ring finger protein 170
IDBP-591694
ring finger protein 170
IDBP-601294
ring finger protein 170
IDBP-598222
ring finger protein 170
IDBP-597522
ring finger protein 170
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:42849637-42897290
Strand Reverse strand
Band p11.21
Transcripts
ENST00000319104 ENSP00000326138
ENST00000319073 ENSP00000325969
ENST00000240159 ENSP00000240159
ENST00000527424 ENSP00000434797
ENST00000526349 ENSP00000435782
ENST00000528318
ENST00000531440 ENSP00000436416
ENST00000524954 ENSP00000437146
ENST00000534961 ENSP00000445725
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000013878
View Gene Order
ENSBTAG00000007630
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.491626 Hs.629385
RefSeq NM_001160223 NM_001160224 NM_001160225 NM_030954 XM_006716404 XM_006716406
HUGO
OMIM
CCDS CCDS55229 CCDS55230 CCDS6138
HPRD 13165
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca