InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adra2b

Summary

InnateDB Gene

IDBG-204829.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adra2b

Gene Name

adrenergic receptor, alpha 2b

Synonyms

[a]2B; Adra-2b; alpha2-C2; alpha2B

Species

Mus musculus

Ensembl Gene

ENSMUSG00000058620

Encoded Proteins

IDBP-204831

adrenergic receptor, alpha 2b

IDBP-272234

adrenergic receptor, alpha 2b

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This intronless gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:127363208-127367221

Strand

Forward strand

Band

Transcripts

ENSMUST00000071902	ENSMUSP00000071798
ENSMUST00000104934	ENSMUSP00000100539

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004935	adrenergic receptor activity
GO:0004938	alpha2-adrenergic receptor activity
GO:0005515	protein binding
GO:0051379	epinephrine binding

Biological Process

GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0001525	angiogenesis
GO:0003056	regulation of vascular smooth muscle contraction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007565	female pregnancy
GO:0030168	platelet activation
GO:0032148	activation of protein kinase B activity
GO:0035625	epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0045666	positive regulation of neuron differentiation
GO:0045777	positive regulation of blood pressure
GO:0070474	positive regulation of uterine smooth muscle contraction
GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway