Mus musculus Gene: Pik3cd

Summary
InnateDB Gene IDBG-205331.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol Pik3cd
Gene Name phosphatidylinositol 3-kinase catalytic delta polypeptide
Synonyms 2410099E07Rik; 2610208K16Rik; AW545373; p110delta
Species Mus musculus
Ensembl Gene ENSMUSG00000039936
Encoded Proteins
IDBP-205333 phosphatidylinositol 3-kinase catalytic delta polypeptide
IDBP-270343 phosphatidylinositol 3-kinase catalytic delta polypeptide
IDBP-270345 phosphatidylinositol 3-kinase catalytic delta polypeptide
IDBP-270347 phosphatidylinositol 3-kinase catalytic delta polypeptide
IDBP-400080 phosphatidylinositol 3-kinase catalytic delta polypeptide
IDBP-400079 phosphatidylinositol 3-kinase catalytic delta polypeptide
IDBP-541939 phosphatidylinositol 3-kinase catalytic delta polypeptide
IDBP-537534 phosphatidylinositol 3-kinase catalytic delta polypeptide
IDBP-532599 phosphatidylinositol 3-kinase catalytic delta polypeptide
IDBP-540224 phosphatidylinositol 3-kinase catalytic delta polypeptide
IDBP-537696 phosphatidylinositol 3-kinase catalytic delta polypeptide
IDBP-717394
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171608:
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4: 149649168-149702571
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000038859  ENSMUSP00000036434
ENSMUST00000105690  ENSMUSP00000101315
ENSMUST00000105689  ENSMUSP00000101314
ENSMUST00000105688  ENSMUSP00000101313
ENSMUST00000122059  ENSMUSP00000113844
ENSMUST00000118704  ENSMUSP00000112863
ENSMUST00000127273  ENSMUSP00000119858
ENSMUST00000131224  ENSMUSP00000115542
ENSMUST00000146612  ENSMUSP00000121843
ENSMUST00000134534  ENSMUSP00000118988
ENSMUST00000156309  ENSMUSP00000115716
ENSMUST00000137430 
ENSMUST00000124510 
ENSMUST00000177654  ENSMUSP00000136045
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein‑Protein  10
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 1
[view]
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total 15 [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Biological Process
GO:0001782 B cell homeostasis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007166 cell surface receptor signaling pathway
GO:0030154 cell differentiation
GO:0042113 B cell activation
GO:0045087 innate immune response
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Gene ID Gene Order Method Confidence Comments
ENSG00000171608 RBBH Low Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
REACT_120469 Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
KEGG
mmu05221  Acute myeloid leukemia
mmu04960  Aldosterone-regulated sodium reabsorption
mmu05146  Amoebiasis
mmu04210  Apoptosis
mmu04662  B cell receptor signaling pathway
mmu05100  Bacterial invasion of epithelial cells
mmu04973  Carbohydrate digestion and absorption
mmu05142  Chagas disease (American trypanosomiasis)
mmu04062  Chemokine signaling pathway
mmu05220  Chronic myeloid leukemia
mmu05210  Colorectal cancer
mmu05213  Endometrial cancer
mmu04012  ErbB signaling pathway
mmu04664  Fc epsilon RI signaling pathway
mmu04666  Fc gamma R-mediated phagocytosis
mmu04510  Focal adhesion
mmu05214  Glioma
mmu05160  Hepatitis C
mmu00562  Inositol phosphate metabolism
mmu04910  Insulin signaling pathway
mmu04630  Jak-STAT signaling pathway
mmu04670  Leukocyte transendothelial migration
mmu04150  MTOR signaling pathway
mmu05218  Melanoma
mmu04650  Natural killer cell mediated cytotoxicity
mmu04722  Neurotrophin signaling pathway
mmu05223  Non-small cell lung cancer
mmu04380  Osteoclast differentiation
mmu05212  Pancreatic cancer
mmu05200  Pathways in cancer
mmu04070  Phosphatidylinositol signaling system
mmu04914  Progesterone-mediated oocyte maturation
mmu05215  Prostate cancer
mmu04810  Regulation of actin cytoskeleton
mmu05211  Renal cell carcinoma
mmu05222  Small cell lung cancer
mmu04660  T cell receptor signaling pathway
mmu04620  Toll-like receptor signaling pathway
mmu05145  Toxoplasmosis
mmu04930  Type II diabetes mellitus
mmu04370  VEGF signaling pathway
INOH
INOH website B cell receptor signaling
INOH website CD4 T cell receptor signaling
INOH website EPO signaling pathway
INOH website FGF signaling pathway
INOH website HGF signaling pathway
INOH website IL-7 signaling
INOH website Insulin receptor signaling
INOH website PDGF signaling pathway
INOH website VEGF signaling pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1 Alpha6Beta4Integrin pathway
NetPath_12 BCR pathway
NetPath_4 EGFR1 pathway
NetPath_14 IL2 pathway
NetPath_15 IL3 pathway
NetPath_16 IL4 pathway
REACTOME
REACT_118700 Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
KEGG
hsa05221  Acute myeloid leukemia
hsa04960  Aldosterone-regulated sodium reabsorption
hsa05146  Amoebiasis
hsa04210  Apoptosis
hsa04662  B cell receptor signaling pathway
hsa05100  Bacterial invasion of epithelial cells
hsa04973  Carbohydrate digestion and absorption
hsa05142  Chagas disease (American trypanosomiasis)
hsa04062  Chemokine signaling pathway
hsa05220  Chronic myeloid leukemia
hsa05210  Colorectal cancer
hsa05213  Endometrial cancer
hsa04012  ErbB signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04510  Focal adhesion
hsa05214  Glioma
hsa05160  Hepatitis C
hsa00562  Inositol phosphate metabolism
hsa04910  Insulin signaling pathway
hsa04630  Jak-STAT signaling pathway
hsa04670  Leukocyte transendothelial migration
hsa04150  MTOR signaling pathway
hsa05218  Melanoma
hsa04650  Natural killer cell mediated cytotoxicity
hsa04722  Neurotrophin signaling pathway
hsa05223  Non-small cell lung cancer
hsa04380  Osteoclast differentiation
hsa05212  Pancreatic cancer
hsa05200  Pathways in cancer
hsa04070  Phosphatidylinositol signaling system
hsa04914  Progesterone-mediated oocyte maturation
hsa05215  Prostate cancer
hsa04810  Regulation of actin cytoskeleton
hsa05211  Renal cell carcinoma
hsa05222  Small cell lung cancer
hsa04660  T cell receptor signaling pathway
hsa04620  Toll-like receptor signaling pathway
hsa05145  Toxoplasmosis
hsa04930  Type II diabetes mellitus
hsa04370  VEGF signaling pathway
INOH
INOH website B cell receptor signaling
INOH website CD4 T cell receptor signaling
INOH website EPO signaling pathway
INOH website FGF signaling pathway
INOH website HGF signaling pathway
INOH website IGF1 signaling pathway
INOH website IL-7 signaling
INOH website Inositol phosphate metabolism
INOH website Insulin receptor signaling
INOH website PDGF signaling pathway
INOH website VEGF signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt O35904 
TrEMBL B0QZL5 B1AS24 B1AS25 B1AS26 B1AS27 B1AS28 Q3T9Y0 Q3TBW3 Q3UDT3 Q8CI98
UniProt Splice Variant
Entrez Gene 18707 
UniGene Mm.229108 Mm.474147
RefSeq NM_001029837  NM_001164049  NM_001164050  NM_001164051  NM_001164052  NM_008840 
OMIM
CCDS CCDS51380  CCDS51381  CCDS51382  CCDS51383  CCDS51384 
HPRD
IMGT
MGI ID MGI:1098211 
MGI Symbol Pik3cd
EMBL AF532989 AK149935 AK171025 AK172222 AL607078 AL626808 BC035203 CH466594 CT010349 CU207384 U86587
GenPept AAC25676  AAH35203  AAN05615  BAE29178  BAE42194  BAE42890  CAJ18557  CAM23913  CAM23914  CAM23915  CAM23917  CAM23918  CAM23919  CAM23920  CAM23921  CAQ11740  CAQ11741  CAQ51666  CAQ51667  CAQ51668  CAQ51669  CAQ51670  CAQ51671  CAQ51672  CAQ51673  CAQ51674  CAQ51675  EDL14872 
ImmGen Pik3cd (murine) 
RNA Seq Atlas 18707