Version 5.4
| Mus musculus Gene: Pik3cd | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-205331.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Pik3cd | ||||||||||||||||||||||
| Gene Name | phosphatidylinositol 3-kinase catalytic delta polypeptide | ||||||||||||||||||||||
| Synonyms | 2410099E07Rik; 2610208K16Rik; AW545373; p110delta | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000039936 | ||||||||||||||||||||||
| Encoded Proteins |
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||
| Summary |
Pik3cd regulates Clec4n signalling and the generation of Th2 and Th17 immunity.
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| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171608:
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 4:149649168-149702571 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | E2 | ||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
GPCR downstream signaling pathway
PI3K/AKT activation pathway
Synthesis of PIPs at the plasma membrane pathway
Disease pathway
Hemostasis pathway
Signaling by GPCR pathway
Interleukin-2 signaling pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
PI Metabolism pathway
Cytokine Signaling in Immune system pathway
PIP3 activates AKT signaling pathway
Metabolism pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Metabolism of lipids and lipoproteins pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
Signaling by EGFR pathway
GPVI-mediated activation cascade pathway
Interleukin receptor SHC signaling pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Fc epsilon receptor (FCERI) signaling pathway
Signaling by Interleukins pathway
PI3K/AKT Signaling in Cancer pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
GAB1 signalosome pathway
Phospholipid metabolism pathway
NGF signalling via TRKA from the plasma membrane pathway
G-protein beta:gamma signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
G beta:gamma signalling through PI3Kgamma pathway
Signaling by FGFR pathway
Signaling by EGFR in Cancer pathway
Regulation of signaling by CBL pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
Endometrial cancer pathway
Renal cell carcinoma pathway
ErbB signaling pathway pathway
Type II diabetes mellitus pathway
VEGF signaling pathway pathway
Jak-STAT signaling pathway pathway
Insulin signaling pathway pathway
Acute myeloid leukemia pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Colorectal cancer pathway
Fc epsilon RI signaling pathway pathway
Melanoma pathway
Natural killer cell mediated cytotoxicity pathway
Phosphatidylinositol signaling system pathway
Regulation of actin cytoskeleton pathway
Glioma pathway
mTOR signaling pathway pathway
Small cell lung cancer pathway
Leukocyte transendothelial migration pathway
Apoptosis pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
Inositol phosphate metabolism pathway
Non-small cell lung cancer pathway
Focal adhesion pathway
B cell receptor signaling pathway pathway
Pancreatic cancer pathway
Fc gamma R-mediated phagocytosis pathway
Chemokine signaling pathway pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
Aldosterone-regulated sodium reabsorption pathway
Amoebiasis pathway
Osteoclast differentiation pathway
Carbohydrate digestion and absorption pathway
Toxoplasmosis pathway
Hepatitis C pathway
Chagas disease (American trypanosomiasis) pathway
Bacterial invasion of epithelial cells pathway
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| INOH |
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
B cell receptor signaling pathway
EPO signaling pathway pathway
FGF signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
HGF signaling pathway pathway
PDGF signaling pathway pathway
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| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
Alpha6Beta4Integrin pathway
EGFR1 pathway
BCR pathway
IL2 pathway
IL3 pathway
IL4 pathway
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| REACTOME |
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Regulation of signaling by CBL pathway
Interleukin receptor SHC signaling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Interleukin-2 signaling pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
GPVI-mediated activation cascade pathway
PI3K/AKT activation pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
G beta:gamma signalling through PI3Kgamma pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
PI-3K cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Synthesis of PIPs at the plasma membrane pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Metabolism of lipids and lipoproteins pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Adaptive Immune System pathway
Immune System pathway
Signaling by Interleukins pathway
NGF signalling via TRKA from the plasma membrane pathway
PI Metabolism pathway
Phospholipid metabolism pathway
PI3K/AKT Signaling in Cancer pathway
Metabolism pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
Hemostasis pathway
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| KEGG |
Regulation of actin cytoskeleton pathway
mTOR signaling pathway pathway
Acute myeloid leukemia pathway
VEGF signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Colorectal cancer pathway
Non-small cell lung cancer pathway
Inositol phosphate metabolism pathway
ErbB signaling pathway pathway
Renal cell carcinoma pathway
Apoptosis pathway
Melanoma pathway
Endometrial cancer pathway
Leukocyte transendothelial migration pathway
Glioma pathway
Small cell lung cancer pathway
Phosphatidylinositol signaling system pathway
Insulin signaling pathway pathway
B cell receptor signaling pathway pathway
Prostate cancer pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Type II diabetes mellitus pathway
Natural killer cell mediated cytotoxicity pathway
Chronic myeloid leukemia pathway
Pancreatic cancer pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
Aldosterone-regulated sodium reabsorption pathway
Amoebiasis pathway
Bacterial invasion of epithelial cells pathway
Chagas disease (American trypanosomiasis) pathway
Osteoclast differentiation pathway
Toxoplasmosis pathway
Carbohydrate digestion and absorption pathway
Hepatitis C pathway
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| INOH |
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
B cell receptor signaling pathway
EPO signaling pathway pathway
FGF signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
HGF signaling pathway pathway
IGF1 signaling pathway pathway
Inositol phosphate metabolism pathway
PDGF signaling pathway pathway
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| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | Mm.229108 Mm.474147 | ||||||||||||||||||||||
| RefSeq | NM_001029837 NM_001164049 NM_001164050 NM_001164051 NM_001164052 NM_008840 XM_006536008 XM_006536011 XM_006536013 XM_006536015 XM_006538649 XM_006538650 XM_006538651 XM_006538652 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS51380 CCDS51381 CCDS51382 CCDS51383 CCDS51384 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||