Mus musculus Gene: Pik3cd
Summary
InnateDB Gene IDBG-205331.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pik3cd
Gene Name phosphatidylinositol 3-kinase catalytic delta polypeptide
Synonyms 2410099E07Rik; 2610208K16Rik; AW545373; p110delta;
Species Mus musculus
Ensembl Gene ENSMUSG00000039936
Encoded Proteins
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
Protein Structure
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171608:
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:149649168-149702571
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000038859 ENSMUSP00000036434
ENSMUST00000105690 ENSMUSP00000101315
ENSMUST00000105689 ENSMUSP00000101314
ENSMUST00000105688 ENSMUSP00000101313
ENSMUST00000122059 ENSMUSP00000113844
ENSMUST00000118704 ENSMUSP00000112863
ENSMUST00000127273 ENSMUSP00000119858
ENSMUST00000131224 ENSMUSP00000115542
ENSMUST00000146612 ENSMUSP00000121843
ENSMUST00000134534 ENSMUSP00000118988
ENSMUST00000156309 ENSMUSP00000115716
ENSMUST00000137430
ENSMUST00000124510
ENSMUST00000177654 ENSMUSP00000136045
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Biological Process
GO:0001782 B cell homeostasis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007166 cell surface receptor signaling pathway
GO:0030154 cell differentiation
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0042113 B cell activation
GO:0045087 innate immune response
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
GPCR downstream signaling pathway
PI3K/AKT activation pathway
Synthesis of PIPs at the plasma membrane pathway
Disease pathway
Hemostasis pathway
Signaling by GPCR pathway
Interleukin-2 signaling pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
PI Metabolism pathway
Cytokine Signaling in Immune system pathway
PIP3 activates AKT signaling pathway
Metabolism pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Metabolism of lipids and lipoproteins pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
Signaling by EGFR pathway
GPVI-mediated activation cascade pathway
Interleukin receptor SHC signaling pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Fc epsilon receptor (FCERI) signaling pathway
Signaling by Interleukins pathway
PI3K/AKT Signaling in Cancer pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
GAB1 signalosome pathway
Phospholipid metabolism pathway
NGF signalling via TRKA from the plasma membrane pathway
G-protein beta:gamma signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
G beta:gamma signalling through PI3Kgamma pathway
Signaling by FGFR pathway
Signaling by EGFR in Cancer pathway
Regulation of signaling by CBL pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
DAP12 interactions pathway
DAP12 signaling pathway
KEGG
Inositol phosphate metabolism pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Phosphatidylinositol signaling system pathway
mTOR signaling pathway pathway
Apoptosis pathway
VEGF signaling pathway pathway
Osteoclast differentiation pathway
Focal adhesion pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Leukocyte transendothelial migration pathway
Neurotrophin signaling pathway pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Type II diabetes mellitus pathway
Aldosterone-regulated sodium reabsorption pathway
Carbohydrate digestion and absorption pathway
Bacterial invasion of epithelial cells pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Amoebiasis pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Renal cell carcinoma pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Melanoma pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Small cell lung cancer pathway
Non-small cell lung cancer pathway
INOH
PDGF signaling pathway pathway
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
B cell receptor signaling pathway
EPO signaling pathway pathway
FGF signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
HGF signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Alpha6Beta4Integrin pathway
EGFR1 pathway
BCR pathway
IL2 pathway
IL3 pathway
IL4 pathway
REACTOME
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
Metabolism of lipids and lipoproteins pathway
PI-3K cascade pathway
Synthesis of PIPs at the plasma membrane pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Cytokine Signaling in Immune system pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Platelet activation, signaling and aggregation pathway
Signaling by SCF-KIT pathway
G-protein beta:gamma signalling pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
GPVI-mediated activation cascade pathway
Interleukin-2 signaling pathway
Interleukin receptor SHC signaling pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
Signaling by Interleukins pathway
NGF signalling via TRKA from the plasma membrane pathway
PI Metabolism pathway
Phospholipid metabolism pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Metabolism pathway
G beta:gamma signalling through PI3Kgamma pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
Hemostasis pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
Regulation of signaling by CBL pathway
KEGG
Inositol phosphate metabolism pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Phosphatidylinositol signaling system pathway
mTOR signaling pathway pathway
Apoptosis pathway
VEGF signaling pathway pathway
Osteoclast differentiation pathway
Focal adhesion pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Leukocyte transendothelial migration pathway
Neurotrophin signaling pathway pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Type II diabetes mellitus pathway
Aldosterone-regulated sodium reabsorption pathway
Carbohydrate digestion and absorption pathway
Bacterial invasion of epithelial cells pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Amoebiasis pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Renal cell carcinoma pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Melanoma pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Small cell lung cancer pathway
Non-small cell lung cancer pathway
INOH
IGF1 signaling pathway pathway
Inositol phosphate metabolism pathway
PDGF signaling pathway pathway
IL-7 signaling pathway
CD4 T cell receptor signaling pathway
B cell receptor signaling pathway
EPO signaling pathway pathway
FGF signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
HGF signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt O35904
TrEMBL B0QZL5 B1AS24 B1AS25 B1AS26 B1AS27 B1AS28 Q3T9Y0 Q3TBW3 Q3UDT3 Q8CI98
UniProt Splice Variant
Entrez Gene 18707
UniGene Mm.229108 Mm.474147
RefSeq NM_001029837 NM_001164049 NM_001164050 NM_001164051 NM_001164052 NM_008840 XM_006536008 XM_006536011 XM_006536013 XM_006536015 XM_006538649 XM_006538650 XM_006538651 XM_006538652
OMIM
CCDS CCDS51380 CCDS51381 CCDS51382 CCDS51383 CCDS51384
HPRD
IMGT
MGI ID MGI:1098211
MGI Symbol Pik3cd
EMBL AF532989 AK149935 AK171025 AK172222 AL607078 AL626808 BC035203 CH466594 CT010349 CU207384 U86587
GenPept AAC25676 AAH35203 AAN05615 BAE29178 BAE42194 BAE42890 CAJ18557 CAM23914 CAQ51667 EDL14872
ImmGen Pik3cd (murine)
RNA Seq Atlas 18707