Mus musculus Gene: Pik3cd
Summary
InnateDB Gene IDBG-205331.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Pik3cd
Gene Name phosphatidylinositol 3-kinase catalytic delta polypeptide
Synonyms 2410099E07Rik; 2610208K16Rik; AW545373; p110delta;
Species Mus musculus
Ensembl Gene ENSMUSG00000039936
Encoded Proteins
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic delta polypeptide
Protein Structure
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171608:
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:149649168-149702571
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000038859 ENSMUSP00000036434
ENSMUST00000105690 ENSMUSP00000101315
ENSMUST00000105689 ENSMUSP00000101314
ENSMUST00000105688 ENSMUSP00000101313
ENSMUST00000122059 ENSMUSP00000113844
ENSMUST00000118704 ENSMUSP00000112863
ENSMUST00000127273 ENSMUSP00000119858
ENSMUST00000131224 ENSMUSP00000115542
ENSMUST00000146612 ENSMUSP00000121843
ENSMUST00000134534 ENSMUSP00000118988
ENSMUST00000156309 ENSMUSP00000115716
ENSMUST00000137430
ENSMUST00000124510
ENSMUST00000177654 ENSMUSP00000136045
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Biological Process
GO:0001782 B cell homeostasis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007166 cell surface receptor signaling pathway
GO:0030154 cell differentiation
GO:0042113 B cell activation
GO:0045087 innate immune response
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers pathway
KEGG
Amoebiasis pathway
Osteoclast differentiation pathway
Carbohydrate digestion and absorption pathway
Aldosterone-regulated sodium reabsorption pathway
Toxoplasmosis pathway
Hepatitis C pathway
Chagas disease (American trypanosomiasis) pathway
Bacterial invasion of epithelial cells pathway
Endometrial cancer pathway
Renal cell carcinoma pathway
ErbB signaling pathway pathway
Type II diabetes mellitus pathway
VEGF signaling pathway pathway
Jak-STAT signaling pathway pathway
Insulin signaling pathway pathway
Acute myeloid leukemia pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Colorectal cancer pathway
Fc epsilon RI signaling pathway pathway
Melanoma pathway
Natural killer cell mediated cytotoxicity pathway
Phosphatidylinositol signaling system pathway
Regulation of actin cytoskeleton pathway
Glioma pathway
MTOR signaling pathway pathway
Small cell lung cancer pathway
Leukocyte transendothelial migration pathway
Apoptosis pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
Inositol phosphate metabolism pathway
Non-small cell lung cancer pathway
Focal adhesion pathway
B cell receptor signaling pathway pathway
Pancreatic cancer pathway
Pathways in cancer pathway
Neurotrophin signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Chemokine signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
INOH
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
EPO signaling pathway pathway
B cell receptor signaling pathway
VEGF signaling pathway pathway
Insulin receptor signaling pathway
FGF signaling pathway pathway
PDGF signaling pathway pathway
HGF signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Alpha6Beta4Integrin pathway
EGFR1 pathway
BCR pathway
IL2 pathway
IL3 pathway
IL4 pathway
REACTOME
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers pathway
KEGG
Glioma pathway
Small cell lung cancer pathway
Phosphatidylinositol signaling system pathway
Insulin signaling pathway pathway
B cell receptor signaling pathway pathway
Prostate cancer pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Type II diabetes mellitus pathway
Natural killer cell mediated cytotoxicity pathway
Chronic myeloid leukemia pathway
Pancreatic cancer pathway
Regulation of actin cytoskeleton pathway
MTOR signaling pathway pathway
Acute myeloid leukemia pathway
VEGF signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Colorectal cancer pathway
Non-small cell lung cancer pathway
Inositol phosphate metabolism pathway
ErbB signaling pathway pathway
Renal cell carcinoma pathway
Apoptosis pathway
Melanoma pathway
Endometrial cancer pathway
Leukocyte transendothelial migration pathway
Toxoplasmosis pathway
Carbohydrate digestion and absorption pathway
Hepatitis C pathway
Aldosterone-regulated sodium reabsorption pathway
Amoebiasis pathway
Bacterial invasion of epithelial cells pathway
Chagas disease (American trypanosomiasis) pathway
Osteoclast differentiation pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
INOH
CD4 T cell receptor signaling pathway
B cell receptor signaling pathway
IL-7 signaling pathway
Insulin receptor signaling pathway
FGF signaling pathway pathway
EPO signaling pathway pathway
HGF signaling pathway pathway
VEGF signaling pathway pathway
PDGF signaling pathway pathway
Inositol phosphate metabolism pathway
IGF1 signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt O35904
TrEMBL B0QZL5 B1AS24 B1AS25 B1AS26 B1AS27 B1AS28 Q3T9Y0 Q3TBW3 Q3UDT3 Q8CI98
UniProt Splice Variant
Entrez Gene 18707
UniGene Mm.229108 Mm.474147
RefSeq NM_001029837 NM_001164049 NM_001164050 NM_001164051 NM_001164052 NM_008840
OMIM
CCDS CCDS51380 CCDS51381 CCDS51382 CCDS51383 CCDS51384
HPRD
IMGT
MGI ID 1098211 MGI:1098211
MGI Symbol Pik3cd
EMBL AF532989 AK149935 AK171025 AK172222 AL607078 AL626808 BC035203 CH466594 CT010349 CU207384 U86587
GenPept AAC25676 AAH35203 AAN05615 BAE29178 BAE42194 BAE42890 CAJ18557 CAM23913 CAM23914 CAM23915 CAM23917 CAM23918 CAM23919 CAM23920 CAM23921 CAQ11740 CAQ11741 CAQ51666 CAQ51667 CAQ51668 CAQ51669 CAQ51670 CAQ51671 CAQ51672 CAQ51673 CAQ51674 CAQ51675 EDL14872
ImmGen Pik3cd (murine)
RNA Seq Atlas 18707