Mus musculus Gene: Il1a
Summary
InnateDB Gene IDBG-205910.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il1a
Gene Name interleukin 1 alpha
Synonyms Il-1a;
Species Mus musculus
Ensembl Gene ENSMUSG00000027399
Encoded Proteins
interleukin 1 alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Under acidic conditions both pro-inflammatory forms of Il1a and Il1b are regulated independently of the NLRP3 inflammasome.
In response to adenovirus infection, the IL1A-IL1R1-CXCR2 signalling axis cooperates with complement to recruit Ly-6G+7/4+ polymorphonuclear leukocytes to the splenic marginal zone (MZ) in the proximity of virus-containing MARCO+ residential MZ macrophages, which are subsequently eliminated.
NLRP3 inflammasome formation is dispensable for alum-induced innate immunity but Il1a and Il1b are both necessary for alum-induced neutrophil influx in vivo.
Il1a directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] Interleukin-1 (IL1A/IL1B) plays a key role in the interaction between local vessel wall cells and invading monocytes to multiply cholesterol-triggered inflammation in the vessel wall.
[Homo sapiens] IFNG interferes with the IL-1/NFKBIZ axis in β-glucan-activated dendritic cells and promotes T cell-mediated immune responses with increased release of IFNG and IL22, and diminished production of IL17A.
[Homo sapiens] CASP4 is a critical regulator of noncanonical inflammasome activation that initiates defence against bacterial pathogens in primary macrophages by mediating cell death and IL1A release
[Homo sapiens] IL1A directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115008:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer\'s disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:129299610-129309972
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000028882 ENSMUSP00000028882
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 3 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005149 interleukin-1 receptor binding
GO:0005507 copper ion binding
GO:0005515 protein binding
Biological Process
GO:0001660 fever generation
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0008285 negative regulation of cell proliferation
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0019221 cytokine-mediated signaling pathway
GO:0034605 cellular response to heat
GO:0035234 ectopic germ cell programmed cell death
GO:0045086 positive regulation of interleukin-2 biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045766 positive regulation of angiogenesis
GO:0045840 positive regulation of mitosis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046688 response to copper ion
GO:0050715 positive regulation of cytokine secretion
GO:0051781 positive regulation of cell division
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005615 extracellular space
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cytokine Signaling in Immune system pathway
Immune System pathway
Signaling by Interleukins pathway
Interleukin-1 signaling pathway
KEGG
MAPK signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Apoptosis pathway
Osteoclast differentiation pathway
Hematopoietic cell lineage pathway
Type I diabetes mellitus pathway
Prion diseases pathway
Leishmaniasis pathway
Graft-versus-host disease pathway
INOH
GPCR signaling pathway
IL-1 signaling pathway pathway
JAK STAT pathway and regulation pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
IL1 pathway
REACTOME
Cellular responses to stress pathway
Cytokine Signaling in Immune system pathway
Interleukin-1 processing pathway
Immune System pathway
Cellular Senescence pathway
Signaling by Interleukins pathway
Interleukin-1 signaling pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Interleukin-1 signaling pathway
Signaling by Interleukins pathway
KEGG
MAPK signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Apoptosis pathway
Osteoclast differentiation pathway
Hematopoietic cell lineage pathway
Type I diabetes mellitus pathway
Prion diseases pathway
Leishmaniasis pathway
Graft-versus-host disease pathway
INOH
GPCR signaling pathway
IL-1 signaling pathway pathway
JAK STAT pathway and regulation pathway
PID BIOCARTA
Nf-kb signaling pathway [Biocarta view]
Stress induction of hsp regulation [Biocarta view]
Signal transduction through il1r [Biocarta view]
Gata3 participate in activating the th2 cytokine genes expression [Biocarta view]
Il-10 anti-inflammatory signaling pathway [Biocarta view]
PID NCI
IL1-mediated signaling events
a6b1 and a6b4 Integrin signaling
Validated transcriptional targets of deltaNp63 isoforms
Cross-References
SwissProt P01582
TrEMBL Q3U0Y6
UniProt Splice Variant
Entrez Gene 16175
UniGene Mm.15534
RefSeq NM_010554 XM_006498792 XM_006498793
OMIM
CCDS CCDS16725
HPRD
IMGT
MGI ID MGI:96542
MGI Symbol Il1a
EMBL AF010237 AK156449 AY902318 BC003727 CH466519 X01450
GenPept AAC28999 AAH03727 AAX90603 BAE33715 CAA25682 EDL28237
RNA Seq Atlas 16175