Version 5.4
Mus musculus Gene: Tmc2
Summary
InnateDB Gene IDBG-206204.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmc2
Gene Name transmembrane channel-like gene family 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000060332
Encoded Proteins
IDBP-206206
transmembrane channel-like gene family 2
IDBP-627792
transmembrane channel-like gene family 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149488:
This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, expression in the inner ear suggests that it may be crucial for normal auditory function. Mutations in this gene may underlie hereditary disorders of balance and hearing. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:130195194-130264445
Strand Forward strand
Band F1
Transcripts
ENSMUST00000077988 ENSMUSP00000077139
ENSMUST00000166774 ENSMUSP00000125843
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005245 voltage-gated calcium channel activity
Biological Process
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0060005 vestibular reflex
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0016021 integral component of membrane
GO:0032426 stereocilium bundle tip
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000149488
View Gene Order
ENSBTAG00000018811
Not yet available
Cross-References
SwissProt Q8R4P4
TrEMBL
UniProt Splice Variant
Entrez Gene 192140
UniGene Mm.219546
RefSeq NM_138655
OMIM
CCDS CCDS16736
HPRD
IMGT
MGI ID MGI:2151017
MGI Symbol Tmc2
EMBL AF417581 AY263156
GenPept AAL86402 AAP35264
RNA Seq Atlas 192140

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca