InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Idh3b

Summary

InnateDB Gene

IDBG-206291.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Idh3b

Gene Name

isocitrate dehydrogenase 3 (NAD+) beta

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027406

Encoded Proteins

IDBP-206293

isocitrate dehydrogenase 3 (NAD+) beta

IDBP-789815

isocitrate dehydrogenase 3 (NAD+) beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101365:
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:130279309-130284547

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028892	ENSMUSP00000028892
ENSMUST00000149843
ENSMUST00000124868
ENSMUST00000184538	ENSMUSP00000139331

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004449	isocitrate dehydrogenase (NAD+) activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287	NAD binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006102	isocitrate metabolic process
GO:0006103	2-oxoglutarate metabolic process
GO:0006734	NADH metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000101365

View Gene Order

ENSBTAG00000018813

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00020

Citrate cycle (TCA cycle) pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_1785

Citric acid cycle (TCA cycle) pathway

REACT_1046

Pyruvate metabolism and Citric Acid (TCA) cycle pathway

REACT_111083

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_111217

Metabolism pathway

REACT_215469

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_219139

Metabolism pathway

REACT_220485

Pyruvate metabolism and Citric Acid (TCA) cycle pathway

REACT_227707

Citric acid cycle (TCA cycle) pathway

KEGG

hsa00020

Citrate cycle (TCA cycle) pathway

INOH

INOH website

Citrate cycle pathway

PID NCI

Cross-References

SwissProt

TrEMBL

Q91VA7 V9GXV0

UniProt Splice Variant

Entrez Gene

170718

UniGene

Mm.29590 Mm.486612

RefSeq

NM_130884 XM_006498824

OMIM

CCDS

CCDS16738

HPRD

IMGT

MGI ID

MGI:2158650

MGI Symbol

Idh3b

EMBL

AL833804 AY035212 BC009022 CH466519

GenPept

AAH09022 AAK64606 EDL28255

RNA Seq Atlas

170718