Version 5.4
Mus musculus Gene: Tbx2
Summary
InnateDB Gene IDBG-206716.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbx2
Gene Name T-box 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000000093
Encoded Proteins
IDBP-206718
T-box 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121068:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:85832551-85841948
Strand Forward strand
Band C
Transcripts
ENSMUST00000000095 ENSMUSP00000000095
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0003007 heart morphogenesis
GO:0003148 outflow tract septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007521 muscle cell fate determination
GO:0007569 cell aging
GO:0008284 positive regulation of cell proliferation
GO:0035909 aorta morphogenesis
GO:0036302 atrioventricular canal development
GO:0042733 embryonic digit morphogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048738 cardiac muscle tissue development
GO:0060021 palate development
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060465 pharynx development
GO:0060560 developmental growth involved in morphogenesis
GO:0060596 mammary placode formation
GO:0090398 cellular senescence
GO:1901208 negative regulation of heart looping
GO:1901211 negative regulation of cardiac chamber formation
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000121068
View Gene Order
ENSBTAG00000014278
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q60707
TrEMBL Q3UET7
UniProt Splice Variant
Entrez Gene 21385
UniGene Mm.287052 Mm.407595 Mm.481479
RefSeq NM_009324
OMIM
CCDS CCDS36266
HPRD
IMGT
MGI ID MGI:98494
MGI Symbol Tbx2
EMBL AF244917 AK149348 AL596324 AL662910 BC156393 CH466556 U15566
GenPept AAC52697 AAF90050 BAE28824 CAI25161 CAI25309 EDL15775
RNA Seq Atlas 21385

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca