Version 5.4
Mus musculus Gene: Kcnab2
Summary
InnateDB Gene IDBG-206719.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcnab2
Gene Name potassium voltage-gated channel, shaker-related subfamily, beta member 2
Synonyms F5; I2rf5; Kcnb3; kv-beta-2
Species Mus musculus
Ensembl Gene ENSMUSG00000028931
Encoded Proteins
IDBP-206721
potassium voltage-gated channel, shaker-related subfamily, beta member 2
IDBP-270430
potassium voltage-gated channel, shaker-related subfamily, beta member 2
IDBP-542357
potassium voltage-gated channel, shaker-related subfamily, beta member 2
IDBP-532615
potassium voltage-gated channel, shaker-related subfamily, beta member 2
IDBP-539023
potassium voltage-gated channel, shaker-related subfamily, beta member 2
IDBP-535391
potassium voltage-gated channel, shaker-related subfamily, beta member 2
IDBP-535774
potassium voltage-gated channel, shaker-related subfamily, beta member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000069424:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:152390742-152477871
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000030768 ENSMUSP00000030768
ENSMUST00000105648 ENSMUSP00000101273
ENSMUST00000159840 ENSMUSP00000124156
ENSMUST00000160884 ENSMUSP00000125058
ENSMUST00000159186 ENSMUSP00000124588
ENSMUST00000159844
ENSMUST00000161496
ENSMUST00000161236 ENSMUSP00000125270
ENSMUST00000159435
ENSMUST00000162200
ENSMUST00000162165
ENSMUST00000161844
ENSMUST00000162518
ENSMUST00000162017 ENSMUSP00000123939
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005249 voltage-gated potassium channel activity
GO:0005515 protein binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006813 potassium ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0051291 protein heterooligomerization
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
GO:0044224 juxtaparanode region of axon
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000069424
View Gene Order
ENSBTAG00000008125
Not yet available
Pathways
NETPATH
REACTOME
REACT_202800
Potassium Channels pathway
REACT_259290
Neuronal System pathway
REACT_199077
Voltage gated Potassium channels pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75770
Voltage gated Potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
REACT_225032
Neuronal System pathway
REACT_224502
Voltage gated Potassium channels pathway
REACT_212420
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.388924 Mm.490885
RefSeq NM_001252654 NM_001252655 NM_001252656 NM_010598 XM_006538581 XM_006538582
OMIM
CCDS CCDS19000 CCDS57316
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca