InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mafk

Summary

InnateDB Gene

IDBG-206764.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mafk

Gene Name

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)

Synonyms

AW061068; NF-E2; Nfe2u

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018143

Encoded Proteins

IDBP-206766

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)

IDBP-259399

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198517:
The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:139791513-139802653

Strand

Forward strand

Band

Transcripts

ENSMUST00000018287	ENSMUSP00000018287
ENSMUST00000110836	ENSMUSP00000106460
ENSMUST00000151577

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0001221	transcription cofactor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007399	nervous system development

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000198517

View Gene Order

ENSBTAG00000019303

Not yet available

Pathways

NETPATH

REACTOME

REACT_224553

Hemostasis pathway

REACT_198649

Factors involved in megakaryocyte development and platelet production pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_24970

Factors involved in megakaryocyte development and platelet production pathway

REACT_604

Hemostasis pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.157313 Mm.416672

RefSeq

NM_010757 XM_006504653

OMIM

CCDS

CCDS19814

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas