Version 5.4
Mus musculus Gene: Tnfrsf14
Summary
InnateDB Gene IDBG-207237.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnfrsf14
Gene Name tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000042333
Encoded Proteins
IDBP-207239
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
IDBP-532271
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
IDBP-540598
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157873:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. [provided by RefSeq, Jul 2008]
This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:154922210-154928563
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000045919 ENSMUSP00000045240
ENSMUST00000123514 ENSMUSP00000116757
ENSMUST00000152687 ENSMUSP00000117890
ENSMUST00000137803
ENSMUST00000145296
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 71 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0002741 positive regulation of cytokine secretion involved in immune response
GO:0046642 negative regulation of alpha-beta T cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:2000406 positive regulation of T cell migration
Cellular Component
GO:0009897 external side of plasma membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000157873
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19344
Costimulation by the CD28 family pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.488706
RefSeq NM_178931 XM_006538830 XM_006538831
OMIM
CCDS CCDS19017
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca