InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ski

Summary

InnateDB Gene

IDBG-207475.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ski

Gene Name

ski sarcoma viral oncogene homolog (avian)

Synonyms

2310012I02Rik; 2610001A11Rik; AA062172; AA589460; BC004088

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029050

Encoded Proteins

IDBP-207477

ski sarcoma viral oncogene homolog (avian)

IDBP-207479

ski sarcoma viral oncogene homolog (avian)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157933:
This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:155154075-155222592

Strand

Reverse strand

Band

Transcripts

ENSMUST00000030917	ENSMUSP00000030917
ENSMUST00000084103	ENSMUSP00000081120
ENSMUST00000129314

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0031625	ubiquitin protein ligase binding
GO:0046332	SMAD binding
GO:0046811	histone deacetylase inhibitor activity
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001843	neural tube closure
GO:0002089	lens morphogenesis in camera-type eye
GO:0006351	transcription, DNA-templated
GO:0008285	negative regulation of cell proliferation
GO:0009948	anterior/posterior axis specification
GO:0010626	negative regulation of Schwann cell proliferation
GO:0014902	myotube differentiation
GO:0021772	olfactory bulb development
GO:0022011	myelination in peripheral nervous system
GO:0030326	embryonic limb morphogenesis
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0031064	negative regulation of histone deacetylation
GO:0032926	negative regulation of activin receptor signaling pathway
GO:0035019	somatic stem cell maintenance
GO:0042981	regulation of apoptotic process
GO:0043010	camera-type eye development
GO:0043388	positive regulation of DNA binding
GO:0043585	nose morphogenesis
GO:0045668	negative regulation of osteoblast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048147	negative regulation of fibroblast proliferation
GO:0048593	camera-type eye morphogenesis
GO:0048741	skeletal muscle fiber development
GO:0060021	palate development
GO:0060041	retina development in camera-type eye
GO:0060325	face morphogenesis
GO:0060349	bone morphogenesis
GO:0060395	SMAD protein signal transduction
GO:0070207	protein homotrimerization

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0016604	nuclear body
GO:0016605	PML body
GO:0017053	transcriptional repressor complex
GO:0043234	protein complex