InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cdk11b

Summary

InnateDB Gene

IDBG-207702.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdk11b

Gene Name

cyclin-dependent kinase 11B

Synonyms

AA989746; Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110; CDK11-p46; CDK11-p58; p58

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029062

Encoded Proteins

IDBP-207704

cyclin-dependent kinase 11B

IDBP-270530

cyclin-dependent kinase 11B

IDBP-270534

cyclin-dependent kinase 11B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000248333:
This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported. [provided by RefSeq, Jul 2008]
This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:155624854-155649938

Strand

Forward strand

Band

Transcripts

ENSMUST00000067081	ENSMUSP00000070527
ENSMUST00000105600	ENSMUSP00000101225
ENSMUST00000105598	ENSMUSP00000101223
ENSMUST00000135550
ENSMUST00000149498
ENSMUST00000142513
ENSMUST00000155100
ENSMUST00000143196

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001824	blastocyst development
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0007088	regulation of mitosis
GO:2001234	negative regulation of apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000248333

View Gene Order

Pathways

NETPATH

REACTOME

REACT_27166

Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes pathway

REACT_252217

Transcriptional regulation of white adipocyte differentiation pathway

REACT_200794

Mus musculus biological processes pathway

REACT_188576

Developmental Biology pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.267410

RefSeq

NM_007661 XM_006538507 XM_006538509 XM_006538510 XM_006538511 XM_006538513

OMIM

CCDS

CCDS19033

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas