Homo sapiens Gene: H19

Summary
InnateDB Gene IDBG-20785.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol H19
Gene Name H19, imprinted maternally expressed transcript (non-protein coding)
Synonyms ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; PRO2605; WT2
Species Homo sapiens
Ensembl Gene ENSG00000130600
Encoded Proteins
Entrez Gene
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] This gene expresses a non-coding RNA, and functions as a tumor suppressor. The gene is located in an imprinted region of chromosome 11 near the insulin-like growth factor 2 (IGF2) gene. Expression of this gene and IGF2 are imprinted so that this gene is only expressed from the maternally-inherited chromosome, and IGF2 is only expressed from the paternally-inherited chromosome. A region of paternal-specific methylation upstream of this gene is required for the imprinting of these genes. Mutations in this gene are associated with Beckwith-Wiedemann Syndrome and Wilms tumorigenesis. [provided by RefSeq, Mar 2009]
Gene Information
Type lincRNA
Genomic Location Chromosome 11: 2016406-2022700
Strand Reverse strand
Band p15.5
Transcripts
ENST00000414790 
ENST00000412788 
ENST00000439725 
ENST00000411861 
ENST00000442037 
ENST00000422826 
ENST00000446406 
ENST00000417089 
ENST00000431095 
ENST00000411754 
ENST00000436715 
ENST00000428066 
ENST00000447298 
ENST00000535745 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
 
Gene Ontology
Accession GO Term
Molecular Function
Biological Process
Cellular Component
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 100033819  283120 
UniGene Hs.533566 Hs.731485
RefSeq
HUGO 4713 
OMIM 103280
CCDS
HPRD
IMGT
EMBL
GenPept
ImmGen H19 (murine) 
RNA Seq Atlas 100033819  283120