Homo sapiens Gene: H19
Summary
InnateDB Gene IDBG-20785.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol H19
Gene Name H19, imprinted maternally expressed transcript (non-protein coding)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000130600
Encoded Proteins
Protein Structure
Entrez Gene
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] This gene expresses a non-coding RNA, and functions as a tumor suppressor. The gene is located in an imprinted region of chromosome 11 near the insulin-like growth factor 2 (IGF2) gene. Expression of this gene and IGF2 are imprinted so that this gene is only expressed from the maternally-inherited chromosome, and IGF2 is only expressed from the paternally-inherited chromosome. A region of paternal-specific methylation upstream of this gene is required for the imprinting of these genes. Mutations in this gene are associated with Beckwith-Wiedemann Syndrome and Wilms tumorigenesis. [provided by RefSeq, Mar 2009]
Gene Information
Type processed_transcript
Genomic Location Chromosome 11:1995163-2001470
Strand Reverse strand
Band p15.5
Transcripts
ENST00000414790
ENST00000412788
ENST00000439725
ENST00000411861
ENST00000442037
ENST00000422826
ENST00000446406
ENST00000417089
ENST00000431095
ENST00000411754
ENST00000436715
ENST00000428066
ENST00000447298
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 283120
UniGene Hs.533566 Hs.731485
RefSeq
HUGO HGNC:4713
OMIM 103280 615509
CCDS
HPRD
IMGT
EMBL
GenPept
ImmGen H19 (murine)
RNA Seq Atlas 100033819 283120