Version 5.4
Mus musculus Gene: Prox1
Summary
InnateDB Gene IDBG-208536.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prox1
Gene Name prospero-related homeobox 1
Synonyms A230003G05Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000010175
Encoded Proteins
IDBP-208538
prospero-related homeobox 1
IDBP-717098
IDBP-713715
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117707:
The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:190118035-190170714
Strand Reverse strand
Band H6
Transcripts
ENSMUST00000010319 ENSMUSP00000010319
ENSMUST00000175916 ENSMUSP00000135703
ENSMUST00000177288 ENSMUSP00000135066
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0016922 ligand-dependent nuclear receptor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0050692 DBD domain binding
GO:0050693 LBD domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001709 cell fate determination
GO:0001822 kidney development
GO:0001889 liver development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001945 lymph vessel development
GO:0001946 lymphangiogenesis
GO:0002088 lens development in camera-type eye
GO:0002089 lens morphogenesis in camera-type eye
GO:0002194 hepatocyte cell migration
GO:0006366 transcription from RNA polymerase II promoter
GO:0007420 brain development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010468 regulation of gene expression
GO:0010595 positive regulation of endothelial cell migration
GO:0021542 dentate gyrus development
GO:0021707 cerebellar granule cell differentiation
GO:0030240 skeletal muscle thin filament assembly
GO:0030324 lung development
GO:0031016 pancreas development
GO:0031667 response to nutrient levels
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045071 negative regulation of viral genome replication
GO:0045446 endothelial cell differentiation
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046619 optic placode formation involved in camera-type eye formation
GO:0048839 inner ear development
GO:0048845 venous blood vessel morphogenesis
GO:0055005 ventricular cardiac myofibril assembly
GO:0055009 atrial cardiac muscle tissue morphogenesis
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060059 embryonic retina morphogenesis in camera-type eye
GO:0060214 endocardium formation
GO:0060298 positive regulation of sarcomere organization
GO:0060412 ventricular septum morphogenesis
GO:0060414 aorta smooth muscle tissue morphogenesis
GO:0060421 positive regulation of heart growth
GO:0060836 lymphatic endothelial cell differentiation
GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment
GO:0070309 lens fiber cell morphogenesis
GO:0070365 hepatocyte differentiation
GO:0070858 negative regulation of bile acid biosynthetic process
GO:0072574 hepatocyte proliferation
GO:0097150 neuronal stem cell maintenance
GO:1901978 positive regulation of cell cycle checkpoint
GO:2000179 positive regulation of neural precursor cell proliferation
GO:2000979 positive regulation of forebrain neuron differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000117707
View Gene Order
ENSBTAG00000010978
Not yet available
Cross-References
SwissProt P48437
TrEMBL
UniProt Splice Variant
Entrez Gene 19130
UniGene Mm.132579 Mm.392678 Mm.473483
RefSeq NM_008937 XM_006497124 XM_006497125 XM_006497126 XM_006497128
OMIM
CCDS CCDS35822
HPRD
IMGT
MGI ID MGI:97772
MGI Symbol Prox1
EMBL AF061576 AK052889 AK143179 BC051411
GenPept AAC32824 AAH51411 BAC35190 BAE25293
RNA Seq Atlas 19130

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca