Version 5.4
Mus musculus Gene: Spag9
Summary
InnateDB Gene IDBG-208586.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spag9
Gene Name sperm associated antigen 9
Synonyms 3110018C07Rik; 4733401I23Rik; 4831406C20Rik; AW552012; Jip4; JLP; JSAP2; JSAP2a; Mapk8ip4; syd1
Species Mus musculus
Ensembl Gene ENSMUSG00000020859
Encoded Proteins
IDBP-208588
sperm associated antigen 9
IDBP-208594
sperm associated antigen 9
IDBP-208596
sperm associated antigen 9
IDBP-208598
sperm associated antigen 9
IDBP-208600
sperm associated antigen 9
IDBP-535171
sperm associated antigen 9
IDBP-537592
sperm associated antigen 9
IDBP-533151
sperm associated antigen 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000008294:
This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:93996091-94126085
Strand Forward strand
Band D
Transcripts
ENSMUST00000041956 ENSMUSP00000042271
ENSMUST00000024979 ENSMUSP00000024979
ENSMUST00000075695 ENSMUSP00000075115
ENSMUST00000092777 ENSMUSP00000090452
ENSMUST00000103168 ENSMUSP00000099457
ENSMUST00000132772
ENSMUST00000132605
ENSMUST00000156019 ENSMUSP00000115864
ENSMUST00000132079 ENSMUSP00000118850
ENSMUST00000127066
ENSMUST00000138154
ENSMUST00000153076 ENSMUSP00000117502
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008432 JUN kinase binding
GO:0019894 kinesin binding
GO:0048273 mitogen-activated protein kinase p38 binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0007257 activation of JUN kinase activity
GO:0030335 positive regulation of cell migration
GO:0042147 retrograde transport, endosome to Golgi
GO:0043410 positive regulation of MAPK cascade
GO:0045666 positive regulation of neuron differentiation
GO:0051146 striated muscle cell differentiation
GO:0051260 protein homooligomerization
GO:0090074 negative regulation of protein homodimerization activity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000008294
View Gene Order
ENSBTAG00000012293
Not yet available
Pathways
NETPATH
REACTOME
REACT_253473
Myogenesis pathway
REACT_258600
CDO in myogenesis pathway
REACT_188576
Developmental Biology pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_21402
CDO in myogenesis pathway
REACT_111045
Developmental Biology pathway
REACT_21303
Myogenesis pathway
KEGG
INOH
PID NCI
arf6_traffickingpathway
Arf6 trafficking events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.260737 Mm.401556 Mm.408853 Mm.461445 Mm.479010
RefSeq NM_001025428 NM_001025429 NM_001025430 NM_001199203 NM_001199204 NM_001199205 NM_027569 XM_006534210 XM_006534211 XM_006534212 XM_006534213 XM_006534214 XM_006534215 XM_006534216 XM_006534217 XM_006534218 XM_006534219
OMIM
CCDS CCDS25248 CCDS25249 CCDS36282 CCDS56797
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca