Homo sapiens Gene: GRIN2B
Summary
InnateDB Gene IDBG-20872.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol GRIN2B
Gene Name glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Synonyms GluN2B; hNR3; MRD6; NMDAR2B; NR2B;
Species Homo sapiens
Ensembl Gene ENSG00000150086
Encoded Proteins
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Protein Structure
Entrez Gene
Summary N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:13714144-14133053
Strand Reverse strand
Band p13.1
Transcripts
ENST00000279593 ENSP00000279593
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 70 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 38 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 70 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004970 ionotropic glutamate receptor activity
GO:0004972 N-methyl-D-aspartate selective glutamate receptor activity
GO:0005215 transporter activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0016594 glycine binding
GO:0031749 D2 dopamine receptor binding
GO:0035255 ionotropic glutamate receptor binding
GO:0042165 neurotransmitter binding
GO:0046982 protein heterodimerization activity
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0001508 regulation of action potential
GO:0001662 behavioral fear response
GO:0001701 in utero embryonic development
GO:0001964 startle response
GO:0001967 suckling behavior
GO:0001975 response to amphetamine
GO:0006810 transport
GO:0006812 cation transport
GO:0006816 calcium ion transport
GO:0007215 glutamate receptor signaling pathway
GO:0007268 synaptic transmission
GO:0007423 sensory organ development
GO:0007611 learning or memory
GO:0007612 learning
GO:0007613 memory
GO:0007616 long-term memory
GO:0008306 associative learning
GO:0009743 response to carbohydrate stimulus
GO:0009790 embryo development
GO:0010350 cellular response to magnesium starvation
GO:0010942 positive regulation of cell death
GO:0014049 positive regulation of glutamate secretion
GO:0021766 hippocampus development
GO:0021987 cerebral cortex development
GO:0032026 response to magnesium ion
GO:0034097 response to cytokine stimulus
GO:0042220 response to cocaine
GO:0042596 fear response
GO:0043113 receptor clustering
GO:0043408 regulation of MAPK cascade
GO:0045471 response to ethanol
GO:0048167 regulation of synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048266 behavioral response to pain
GO:0048511 rhythmic process
GO:0050806 positive regulation of synaptic transmission
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051592 response to calcium ion
GO:0051597 response to methylmercury
GO:0051602 response to electrical stimulus
GO:0051707 response to other organism
GO:0060078 regulation of postsynaptic membrane potential
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0060416 response to growth hormone stimulus
GO:0060992 response to fungicide
GO:0070588 calcium ion transmembrane transport
GO:0071230 cellular response to amino acid stimulus
GO:0071287 cellular response to manganese ion
GO:0071359 cellular response to dsRNA
GO:0071363 cellular response to growth factor stimulus
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral to plasma membrane
GO:0008021 synaptic vesicle
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex
GO:0030018 Z disc
GO:0030054 cell junction
GO:0030288 outer membrane-bounded periplasmic space
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0043083 synaptic cleft
GO:0043195 terminal button
GO:0045202 synapse
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Ras activation uopn Ca2+ infux through NMDA receptor pathway
CREB phosphorylation through the activation of CaMKII pathway
Unblocking of NMDA receptor, glutamate binding and activation pathway
KEGG
Amyotrophic lateral sclerosis (ALS) pathway
Systemic lupus erythematosus pathway
Huntington`s disease pathway
Long-term potentiation pathway
Alzheimer`s disease pathway
Neuroactive ligand-receptor interaction pathway
INOH
GPCR Dopamine D1like receptor signaling pathway pathway
PID BIOCARTA
Nitric oxide signaling pathway [Biocarta view]
PID NCI
Reelin signaling pathway
ErbB4 signaling events
Cross-References
SwissProt Q13224
TrEMBL Q59HA9
UniProt Splice Variant
Entrez Gene 2904
UniGene Hs.654430
RefSeq NM_000834
HUGO 4586
OMIM 138252
CCDS CCDS8662
HPRD 00697
IMGT
EMBL AB208850 BC113618 BC113620 U11287 U28758 U28861 U28862 U88963 U90278
GenPept AAA69919 AAA69920 AAA74930 AAB49993 AAB60368 AAD00659 AAI13619 AAI13621 BAD92087
ImmGen GRIN2B (murine)
RNA Seq Atlas 2904