InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sstr4

Summary

InnateDB Gene

IDBG-208948.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sstr4

Gene Name

somatostatin receptor 4

Synonyms

Smstr4; sst4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037014

Encoded Proteins

IDBP-261277

somatostatin receptor 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132671:
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:148395344-148396767

Strand

Forward strand

Band

Transcripts

ENSMUST00000109962

ENSMUSP00000105588

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004994	somatostatin receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0016477	cell migration
GO:0019369	arachidonic acid metabolic process
GO:0030815	negative regulation of cAMP metabolic process
GO:0030900	forebrain development
GO:0038170	somatostatin signaling pathway
GO:0043410	positive regulation of MAPK cascade
GO:0071385	cellular response to glucocorticoid stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000132671

View Gene Order

Pathways

NETPATH

REACTOME

KEGG

mmu04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

P49660

TrEMBL

UniProt Splice Variant

Entrez Gene

20608

UniGene

Mm.35324

RefSeq

NM_009219

OMIM

CCDS

CCDS38260

HPRD

IMGT

MGI ID

MGI:105372

MGI Symbol

Sstr4

EMBL

AK051189 AL935149 AY902332 BC138487 BC138488 U26176

GenPept

AAA67561 AAI38488 AAI38489 AAX90617 BAC34552

RNA Seq Atlas

20608