Version 5.4
| Mus musculus Gene: Prkcb | |||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-208976.6 | ||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||
| Gene Symbol | Prkcb | ||||||||||||||||||||||||||||||||||||
| Gene Name | protein kinase C, beta | ||||||||||||||||||||||||||||||||||||
| Synonyms | A130082F03Rik; PKC-Beta; Pkcb; Prkcb1; Prkcb2 | ||||||||||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000052889 | ||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
protein kinase C, beta
protein kinase C, beta
protein kinase C, beta
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| Protein Structure | |||||||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166501:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 7:122288751-122634402 | ||||||||||||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||||||||||||
| Band | F2 | ||||||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||
| REACTOME |
Nuclear Envelope Breakdown pathway
WNT5A-dependent internalization of FZD4 pathway
Signaling by the B Cell Receptor (BCR) pathway
GPCR downstream signaling pathway
Cell Cycle, Mitotic pathway
Hemostasis pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
Signaling by VEGF pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
beta-catenin independent WNT signaling pathway
VEGFR2 mediated cell proliferation pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
Cell Cycle pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
M Phase pathway
PCP/CE pathway pathway
Activation of NF-kappaB in B cells pathway
Disinhibition of SNARE formation pathway
G alpha (z) signalling events pathway
VEGFA-VEGFR2 Pathway pathway
Depolymerisation of the Nuclear Lamina pathway
Adaptive Immune System pathway
Neuronal System pathway
Trafficking of GluR2-containing AMPA receptors pathway
Response to elevated platelet cytosolic Ca2+ pathway
Mitotic Prophase pathway
Signal Transduction pathway
Trafficking of AMPA receptors pathway
Transmission across Chemical Synapses pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
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| KEGG |
Tight junction pathway
ErbB signaling pathway pathway
VEGF signaling pathway pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Wnt signaling pathway pathway
Gap junction pathway
Fc epsilon RI signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Phosphatidylinositol signaling system pathway
GnRH signaling pathway pathway
MAPK signaling pathway pathway
Long-term potentiation pathway
Glioma pathway
mTOR signaling pathway pathway
Leukocyte transendothelial migration pathway
Long-term depression pathway
Non-small cell lung cancer pathway
Focal adhesion pathway
B cell receptor signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Chemokine signaling pathway pathway
Vascular smooth muscle contraction pathway
Pathways in cancer pathway
Aldosterone-regulated sodium reabsorption pathway
Leishmaniasis pathway
Amoebiasis pathway
Gastric acid secretion pathway
Carbohydrate digestion and absorption pathway
Salivary secretion pathway
Pancreatic secretion pathway
African trypanosomiasis pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
GPCR signaling pathway
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| PID NCI | |||||||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
KitReceptor pathway
Wnt pathway
BCR pathway
IL3 pathway
IL5 pathway
Prolactin pathway
IL11 pathway
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| REACTOME |
Activation of NF-kappaB in B cells pathway
Disinhibition of SNARE formation pathway
Response to elevated platelet cytosolic Ca2+ pathway
G alpha (z) signalling events pathway
Trafficking of GluR2-containing AMPA receptors pathway
Trafficking of AMPA receptors pathway
PCP/CE pathway pathway
WNT5A-dependent internalization of FZD4 pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Neuronal System pathway
Signaling by VEGF pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Cell Cycle pathway
Adaptive Immune System pathway
Immune System pathway
VEGFR2 mediated cell proliferation pathway
M Phase pathway
VEGFA-VEGFR2 Pathway pathway
Mitotic Prophase pathway
Transmission across Chemical Synapses pathway
Cell Cycle, Mitotic pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Signaling by the B Cell Receptor (BCR) pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
Depolymerisation of the Nuclear Lamina pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Nuclear Envelope Breakdown pathway
Hemostasis pathway
Signaling by Wnt pathway
Depolymerisation of the Nuclear Lamina pathway
Trafficking of GluR2-containing AMPA receptors pathway
Signaling by GPCR pathway
M Phase pathway
WNT5A-dependent internalization of FZD4 pathway
VEGFA-VEGFR2 Pathway pathway
Nuclear Envelope Breakdown pathway
Hemostasis pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Immune System pathway
Cell Cycle, Mitotic pathway
Transmission across Chemical Synapses pathway
Platelet activation, signaling and aggregation pathway
VEGFR2 mediated cell proliferation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Signaling by the B Cell Receptor (BCR) pathway
Cell Cycle pathway
Signal Transduction pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
beta-catenin independent WNT signaling pathway
PCP/CE pathway pathway
GPCR downstream signaling pathway
Neuronal System pathway
Mitotic Prophase pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
Signaling by VEGF pathway
Adaptive Immune System pathway
Activation of NF-kappaB in B cells pathway
Trafficking of AMPA receptors pathway
Disinhibition of SNARE formation pathway
G alpha (z) signalling events pathway
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| KEGG |
mTOR signaling pathway pathway
GnRH signaling pathway pathway
Vibrio cholerae infection pathway
VEGF signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Gap junction pathway
Non-small cell lung cancer pathway
Wnt signaling pathway pathway
ErbB signaling pathway pathway
MAPK signaling pathway pathway
Long-term potentiation pathway
Leukocyte transendothelial migration pathway
Tight junction pathway
Glioma pathway
Phosphatidylinositol signaling system pathway
B cell receptor signaling pathway pathway
Focal adhesion pathway
Long-term depression pathway
Natural killer cell mediated cytotoxicity pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Fc gamma R-mediated phagocytosis pathway
Vascular smooth muscle contraction pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
Aldosterone-regulated sodium reabsorption pathway
Leishmaniasis pathway
Gastric acid secretion pathway
Amoebiasis pathway
Pancreatic secretion pathway
Salivary secretion pathway
African trypanosomiasis pathway
Carbohydrate digestion and absorption pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
GPCR signaling pathway
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| PID NCI |
TCR signaling in naïve CD8+ T cells
IL2-mediated signaling events
TCR signaling in naïve CD4+ T cells
Downstream signaling in naïve CD8+ T cells
Ras signaling in the CD4+ TCR pathway
JNK signaling in the CD4+ TCR pathway
Signaling events mediated by VEGFR1 and VEGFR2
Fc-epsilon receptor I signaling in mast cells
VEGFR1 specific signals
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| Cross-References | |||||||||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||
| UniGene | Mm.207496 Mm.401073 Mm.474074 | ||||||||||||||||||||||||||||||||||||
| RefSeq | NM_008855 XM_006507442 | ||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||
| CCDS | CCDS21815 | ||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||||||||||||