|Mus musculus Gene: Il27|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||interleukin 27|
Il27 priming results in an enhanced LPS-induced proinflammatory response in primary monocytes, specifically increasing expression of Il6, Tnf, Ccl3, and Ccl4. (Demonstrated in human)
Influenza virus infection induces pulmonary Il27 production in a type I IFN-alpha/beta receptor (IFNAR) signalling-dependent manner, which sensitizes mice to secondary pneumococcal infection downstream of IFNAR pathway.
|InnateDB Annotation from Orthologs|
[Homo sapiens] IL27, a member of the IL-12 cytokine family, acts as a pro-inflammatory cytokine that regulates the differentiation of naive T helper cells and also possesses anti-inflammatory properties.
[Homo sapiens] IL27 induces a STAT1/3 and NFkappaB dependent pro-inflammatory cytokine profile in human monocytes.
[Homo sapiens] IL27 is a strong inducer of pro-inflammatory cytokine and chemokine expression, including enhancement of IL6, CXCL10 (IP-10), CCL3 (MIP-1alpha), CCL4 (MIP-1beta), and TNF (TNF-alpha) expression in human primary monocytes, the production of which is mediated by STAT1, STAT3, and NF-kappaB activation.
[Homo sapiens] IL27 priming results in enhanced LPS-induced proinflammatory response in human primary monocytes, specifically increasing expression of IL6, TNF, CCL3, and CCL4.
[Homo sapiens] IL27 reduces vacuolar ATPase levels to inhibit phagosome acidification in macrophages.
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197272:
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 7:126589010-126594941|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Possible paralog/unusual divergence/ gene prediction error
|Pathway Predictions based on Human Orthology Data|
IL27-mediated signaling events
|UniProt Splice Variant|
|EMBL||AK152114 AK153466 AY099297 BC119402|
|GenPept||AAI19403 AAM34499 BAE30958 BAE32017|
|RNA Seq Atlas||246779|