Mus musculus Gene: Il27
Summary
InnateDB Gene IDBG-209673.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il27
Gene Name interleukin 27
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000044701
Encoded Proteins
interleukin 27
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Il27 priming results in an enhanced LPS-induced proinflammatory response in primary monocytes, specifically increasing expression of Il6, Tnf, Ccl3, and Ccl4. (Demonstrated in human)
Influenza virus infection induces pulmonary Il27 production in a type I IFN-alpha/beta receptor (IFNAR) signalling-dependent manner, which sensitizes mice to secondary pneumococcal infection downstream of IFNAR pathway.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] IL27, a member of the IL-12 cytokine family, acts as a pro-inflammatory cytokine that regulates the differentiation of naive T helper cells and also possesses anti-inflammatory properties.
[Homo sapiens] IL27 induces a STAT1/3 and NFkappaB dependent pro-inflammatory cytokine profile in human monocytes.
[Homo sapiens] IL27 is a strong inducer of pro-inflammatory cytokine and chemokine expression, including enhancement of IL6, CXCL10 (IP-10), CCL3 (MIP-1alpha), CCL4 (MIP-1beta), and TNF (TNF-alpha) expression in human primary monocytes, the production of which is mediated by STAT1, STAT3, and NF-kappaB activation.
[Homo sapiens] IL27 priming results in enhanced LPS-induced proinflammatory response in human primary monocytes, specifically increasing expression of IL6, TNF, CCL3, and CCL4.
[Homo sapiens] IL27 reduces vacuolar ATPase levels to inhibit phagosome acidification in macrophages.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197272:
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:126589010-126594941
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000058429 ENSMUSP00000054637
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 3 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0045523 interleukin-27 receptor binding
Biological Process
GO:0006954 inflammatory response
GO:0009617 response to bacterium
GO:0042129 regulation of T cell proliferation
GO:0045078 positive regulation of interferon-gamma biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045625 regulation of T-helper 1 cell differentiation
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
IL27-mediated signaling events
Cross-References
SwissProt Q8K3I6
TrEMBL
UniProt Splice Variant
Entrez Gene 246779
UniGene Mm.222632
RefSeq NM_145636
OMIM
CCDS CCDS21835
HPRD
IMGT
MGI ID MGI:2384409
MGI Symbol Il27
EMBL AK152114 AK153466 AY099297 BC119402
GenPept AAI19403 AAM34499 BAE30958 BAE32017
RNA Seq Atlas 246779