Mus musculus Gene: Il27
Summary
InnateDB Gene IDBG-209673.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Il27
Gene Name interleukin 27
Synonyms IL-27; IL-27p28; Il30; p28;
Species Mus musculus
Ensembl Gene ENSMUSG00000044701
Encoded Proteins
interleukin 27
Protein Structure
InnateDB Annotation
Summary
Il27 priming results in an enhanced LPS-induced proinflammatory response in primary monocytes, specifically increasing expression of Il6, Tnf, Ccl3, and Ccl4. (Demonstrated in human)
Influenza virus infection induces pulmonary Il27 production in a type I IFN-alpha/beta receptor (IFNAR) signalling-dependent manner, which sensitizes mice to secondary pneumococcal infection downstream of IFNAR pathway.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] IL27, a member of the IL-12 cytokine family, acts as a pro-inflammatory cytokine that regulates the differentiation of naive T helper cells and also possesses anti-inflammatory properties.
[Homo sapiens] IL27 induces a STAT1/3 and NFkappaB dependent pro-inflammatory cytokine profile in human monocytes.
[Homo sapiens] IL27 is a strong inducer of pro-inflammatory cytokine and chemokine expression, including enhancement of IL6, CXCL10 (IP-10), CCL3 (MIP-1alpha), CCL4 (MIP-1beta), and TNF (TNF-alpha) expression in human primary monocytes, the production of which is mediated by STAT1, STAT3, and NF-kappaB activation.
[Homo sapiens] IL27 priming results in enhanced LPS-induced proinflammatory response in human primary monocytes, specifically increasing expression of IL6, TNF, CCL3, and CCL4.
[Homo sapiens] IL27 reduces vacuolar ATPase levels to inhibit phagosome acidification in macrophages.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197272:
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:126589010-126594941
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000058429 ENSMUSP00000054637
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 3 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0045523 interleukin-27 receptor binding
Biological Process
GO:0006954 inflammatory response
GO:0009617 response to bacterium
GO:0042129 regulation of T cell proliferation
GO:0045078 positive regulation of interferon-gamma biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045625 regulation of T-helper 1 cell differentiation
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
IL27-mediated signaling events
Cross-References
SwissProt Q8K3I6
TrEMBL
UniProt Splice Variant
Entrez Gene 246779
UniGene Mm.222632
RefSeq NM_145636
OMIM
CCDS CCDS21835
HPRD
IMGT
MGI ID 2384409 MGI:2384409
MGI Symbol Il27
EMBL AK152114 AK153466 AY099297 BC119402
GenPept AAI19403 AAM34499 BAE30958 BAE32017
ImmGen Il27 (murine)
RNA Seq Atlas 246779