InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Id1

Summary

InnateDB Gene

IDBG-209844.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Id1

Gene Name

inhibitor of DNA binding 1

Synonyms

AI323524; bHLHb24; D2Wsu140e; Idb1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000042745

Encoded Proteins

IDBP-209846

inhibitor of DNA binding 1

IDBP-261569

inhibitor of DNA binding 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125968:
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:152736251-152737410

Strand

Forward strand

Band

Transcripts

ENSMUST00000038368	ENSMUSP00000092019
ENSMUST00000109824	ENSMUSP00000105449

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	9 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001886	endothelial cell morphogenesis
GO:0006351	transcription, DNA-templated
GO:0007507	heart development
GO:0030509	BMP signaling pathway
GO:0031648	protein destabilization
GO:0032963	collagen metabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0043408	regulation of MAPK cascade
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045668	negative regulation of osteoblast differentiation
GO:0045765	regulation of angiogenesis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046677	response to antibiotic
GO:0060425	lung morphogenesis
GO:0060426	lung vasculature development