Version 5.4
Mus musculus Gene: Hoxb8
Summary
InnateDB Gene IDBG-209874.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hoxb8
Gene Name homeobox B8
Synonyms Hox-2.4
Species Mus musculus
Ensembl Gene ENSMUSG00000056648
Encoded Proteins
IDBP-209876
homeobox B8
IDBP-536915
homeobox B8
IDBP-621928
homeobox B8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120068:
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:96281905-96285315
Strand Forward strand
Band D
Transcripts
ENSMUST00000052650 ENSMUSP00000052496
ENSMUST00000125410 ENSMUSP00000120351
ENSMUST00000168043 ENSMUSP00000128136
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 16 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007625 grooming behavior
GO:0008344 adult locomotory behavior
GO:0009952 anterior/posterior pattern specification
GO:0019233 sensory perception of pain
GO:0021516 dorsal spinal cord development
GO:0045638 negative regulation of myeloid cell differentiation
GO:0048704 embryonic skeletal system morphogenesis
GO:0048705 skeletal system morphogenesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000120068
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.447087
RefSeq NM_010461 XM_006532294 XM_006532295
OMIM
CCDS CCDS25293
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca