Version 5.4
Homo sapiens Gene: GUCY2C
Summary
InnateDB Gene IDBG-20988.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GUCY2C
Gene Name guanylate cyclase 2C (heat stable enterotoxin receptor)
Synonyms DIAR6; GUC2C; MECIL; MUCIL; STAR
Species Homo sapiens
Ensembl Gene ENSG00000070019
Encoded Proteins
IDBP-20990
guanylate cyclase 2C (heat stable enterotoxin receptor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:14612632-14696585
Strand Reverse strand
Band p12.3
Transcripts
ENST00000261170 ENSP00000261170
ENST00000535803
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004383 guanylate cyclase activity
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0015643 toxic substance binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016849 phosphorus-oxygen lyase activity
Biological Process
GO:0006182 cGMP biosynthetic process
GO:0006468 protein phosphorylation
GO:0007168 receptor guanylyl cyclase signaling pathway
GO:0009190 cyclic nucleotide biosynthetic process
GO:0009636 response to toxic substance
GO:0035556 intracellular signal transduction
GO:0042127 regulation of cell proliferation
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042638
View Gene Order
ENSBTAG00000019722
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.524278
RefSeq NM_004963
HUGO
OMIM
CCDS CCDS8664
HPRD 07529
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca