Version 5.4
Mus musculus Gene: Pofut1
Summary
InnateDB Gene IDBG-210039.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pofut1
Gene Name protein O-fucosyltransferase 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000046020
Encoded Proteins
IDBP-210041
protein O-fucosyltransferase 1
IDBP-210043
protein O-fucosyltransferase 1
IDBP-210045
protein O-fucosyltransferase 1
IDBP-261628
protein O-fucosyltransferase 1
IDBP-622185
protein O-fucosyltransferase 1
IDBP-622186
protein O-fucosyltransferase 1
IDBP-622183
protein O-fucosyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101346:
This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:153241533-153270247
Strand Forward strand
Band H1
Transcripts
ENSMUST00000049863 ENSMUSP00000053122
ENSMUST00000099192 ENSMUSP00000096797
ENSMUST00000099191 ENSMUSP00000096796
ENSMUST00000109794 ENSMUSP00000105417
ENSMUST00000123158
ENSMUST00000123487 ENSMUSP00000126395
ENSMUST00000152390 ENSMUSP00000128139
ENSMUST00000170297 ENSMUSP00000126063
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008417 fucosyltransferase activity
GO:0046922 peptide-O-fucosyltransferase activity
Biological Process
GO:0001525 angiogenesis
GO:0001756 somitogenesis
GO:0006004 fucose metabolic process
GO:0006493 protein O-linked glycosylation
GO:0007219 Notch signaling pathway
GO:0007399 nervous system development
GO:0007507 heart development
GO:0036065 fucosylation
GO:0036066 protein O-linked fucosylation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101346
View Gene Order
ENSBTAG00000016231
Not yet available
Pathways
NETPATH
REACTOME
REACT_196492
Pre-NOTCH Processing in the Endoplasmic Reticulum pathway
REACT_196494
Pre-NOTCH Expression and Processing pathway
REACT_188257
Signal Transduction pathway
REACT_231152
Signaling by NOTCH pathway
KEGG
mmu00514
Other types of O-glycan biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_3
Notch pathway
REACTOME
REACT_118722
Pre-NOTCH Processing in the Endoplasmic Reticulum pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_111102
Signal Transduction pathway
REACT_299
Signaling by NOTCH pathway
KEGG
hsa00514
Other types of O-glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.293761
RefSeq NM_080463 XM_006498736
OMIM
CCDS CCDS16909
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca