Version 5.4
Homo sapiens Gene: HACL1
Summary
InnateDB Gene IDBG-21011.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HACL1
Gene Name 2-hydroxyacyl-CoA lyase 1
Synonyms 2-HPCL; HPCL; HPCL2; PHYH2
Species Homo sapiens
Ensembl Gene ENSG00000131373
Encoded Proteins
IDBP-21015
2-hydroxyacyl-CoA lyase 1
IDBP-21017
2-hydroxyacyl-CoA lyase 1
IDBP-366406
2-hydroxyacyl-CoA lyase 1
IDBP-366408
2-hydroxyacyl-CoA lyase 1
IDBP-366409
2-hydroxyacyl-CoA lyase 1
IDBP-366410
2-hydroxyacyl-CoA lyase 1
IDBP-366417
2-hydroxyacyl-CoA lyase 1
IDBP-366419
2-hydroxyacyl-CoA lyase 1
IDBP-366421
2-hydroxyacyl-CoA lyase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:15560704-15601831
Strand Reverse strand
Band p25.1
Transcripts
ENST00000321169 ENSP00000323811
ENST00000383779 ENSP00000373289
ENST00000456194 ENSP00000390699
ENST00000457447 ENSP00000404883
ENST00000451445 ENSP00000403656
ENST00000435217 ENSP00000395278
ENST00000422591 ENSP00000392796
ENST00000421993 ENSP00000391393
ENST00000414979 ENSP00000395352
ENST00000469454
ENST00000460907
ENST00000472857
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 9 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0005102 receptor binding
GO:0016829 lyase activity
GO:0016830 carbon-carbon lyase activity
GO:0030976 thiamine pyrophosphate binding
GO:0042802 identical protein binding
GO:0048037 cofactor binding
Biological Process
GO:0001561 fatty acid alpha-oxidation
GO:0006629 lipid metabolic process
GO:0008152 metabolic process
GO:0019385 methanogenesis, from acetate
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0051259 protein oligomerization
Cellular Component
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021884
View Gene Order
ENSBTAG00000003718
Not yet available
Pathways
NETPATH
REACTOME
REACT_17003
Alpha-oxidation of phytanate pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_16957
Peroxisomal lipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.63290
RefSeq NM_001284413 NM_001284415 NM_001284416 NM_012260
HUGO
OMIM
CCDS CCDS2627 CCDS68360 CCDS68361 CCDS68362
HPRD 09183
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca