InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kpnb1

Summary

InnateDB Gene

IDBG-210164.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kpnb1

Gene Name

karyopherin (importin) beta 1

Synonyms

AA409963; Impnb; IPOB

Species

Mus musculus

Ensembl Gene

ENSMUSG00000001440

Encoded Proteins

IDBP-210166

karyopherin (importin) beta 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108424:
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:97159714-97187881

Strand

Reverse strand

Band

Transcripts

ENSMUST00000001479	ENSMUSP00000001479
ENSMUST00000132633
ENSMUST00000153727

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 124 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	3 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	124 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008536	Ran GTPase binding
GO:0008565	protein transporter activity
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006606	protein import into nucleus
GO:0006610	ribosomal protein import into nucleus
GO:0006886	intracellular protein transport

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0031965	nuclear membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0071782	endoplasmic reticulum tubular network